Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041567372> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2041567372 endingPage "1158" @default.
- W2041567372 startingPage "1151" @default.
- W2041567372 abstract "Murine erythroleukemia cells (MELC) were incubated with BCNU in concentrations from 1 to 160 mu molar. The cytotoxicity was linear with concentration for 10 mu mol ar(GID15) to 40 mu molar (GID95). Incubation of MELC with BCNU induced striking morphological changes in the cell which include multinucleation and cell enlargement which appear to be linear with BCNU concentration in the range from 10 to 40 mu molar. Polykaryon formation was induced in 85% of MELC when exposed to 40 mu molar BCNU and was accompanied by marked increases in chromatin condensation and cellular fragility. The mean generation time for MELC(MGT) was increased from 14 h in control cultures to greater than 48 h in 40 mu molar BCNU. Hemoglobin synthesis in the presence of Me2SO was inhibited by 50% by exposure to 10 mu molar BCNU and to zero by exposure to 40 mu mo lar BCNU. These effects can be observed at 96 h after as little as 3 h of exposure to BCNU. The effects reported above are not reversible after washing cultures and reseeding them in fresh medium lacking BCNU. This is in contrast to cisplatin, another divalent alkylating agent in which the half-life of the crosslinks appears to be much shorter and in which washing and resuspension in fresh unsupplemented medium permits recovery of ability to replicate and to synthesize hemoglobin in the presence of Me2SO. The data supports the idea that the presence of single stranded breaks in DNA are required for induction of hemoglobin synthesis." @default.
- W2041567372 created "2016-06-24" @default.
- W2041567372 creator A5036653516 @default.
- W2041567372 date "1986-01-01" @default.
- W2041567372 modified "2023-10-18" @default.
- W2041567372 title "Interactions of 1–3 bis-(2-chloroethyl)-nitrosourea (NSC 409962) (BCNU) with clone DS19 of murine erythroleukemia cells (MELC)" @default.
- W2041567372 cites W1483219029 @default.
- W2041567372 cites W1495713956 @default.
- W2041567372 cites W1613623364 @default.
- W2041567372 cites W1754890121 @default.
- W2041567372 cites W1898870911 @default.
- W2041567372 cites W1933173848 @default.
- W2041567372 cites W1967301757 @default.
- W2041567372 cites W1979704489 @default.
- W2041567372 cites W2017109949 @default.
- W2041567372 cites W2024326080 @default.
- W2041567372 cites W2027052048 @default.
- W2041567372 cites W2027704123 @default.
- W2041567372 cites W2039820478 @default.
- W2041567372 cites W2042793092 @default.
- W2041567372 cites W2049461710 @default.
- W2041567372 cites W2079826421 @default.
- W2041567372 cites W2169121749 @default.
- W2041567372 cites W2284736532 @default.
- W2041567372 doi "https://doi.org/10.1016/0145-2126(86)90061-5" @default.
- W2041567372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3463836" @default.
- W2041567372 hasPublicationYear "1986" @default.
- W2041567372 type Work @default.
- W2041567372 sameAs 2041567372 @default.
- W2041567372 citedByCount "0" @default.
- W2041567372 crossrefType "journal-article" @default.
- W2041567372 hasAuthorship W2041567372A5036653516 @default.
- W2041567372 hasConcept C106827334 @default.
- W2041567372 hasConcept C109316439 @default.
- W2041567372 hasConcept C13965031 @default.
- W2041567372 hasConcept C151730666 @default.
- W2041567372 hasConcept C153911025 @default.
- W2041567372 hasConcept C161790260 @default.
- W2041567372 hasConcept C178790620 @default.
- W2041567372 hasConcept C185592680 @default.
- W2041567372 hasConcept C202271784 @default.
- W2041567372 hasConcept C202751555 @default.
- W2041567372 hasConcept C25642318 @default.
- W2041567372 hasConcept C2776694085 @default.
- W2041567372 hasConcept C2778119113 @default.
- W2041567372 hasConcept C2778917026 @default.
- W2041567372 hasConcept C2780147359 @default.
- W2041567372 hasConcept C2994067411 @default.
- W2041567372 hasConcept C43617362 @default.
- W2041567372 hasConcept C54355233 @default.
- W2041567372 hasConcept C552990157 @default.
- W2041567372 hasConcept C55493867 @default.
- W2041567372 hasConcept C81089528 @default.
- W2041567372 hasConcept C86803240 @default.
- W2041567372 hasConceptScore W2041567372C106827334 @default.
- W2041567372 hasConceptScore W2041567372C109316439 @default.
- W2041567372 hasConceptScore W2041567372C13965031 @default.
- W2041567372 hasConceptScore W2041567372C151730666 @default.
- W2041567372 hasConceptScore W2041567372C153911025 @default.
- W2041567372 hasConceptScore W2041567372C161790260 @default.
- W2041567372 hasConceptScore W2041567372C178790620 @default.
- W2041567372 hasConceptScore W2041567372C185592680 @default.
- W2041567372 hasConceptScore W2041567372C202271784 @default.
- W2041567372 hasConceptScore W2041567372C202751555 @default.
- W2041567372 hasConceptScore W2041567372C25642318 @default.
- W2041567372 hasConceptScore W2041567372C2776694085 @default.
- W2041567372 hasConceptScore W2041567372C2778119113 @default.
- W2041567372 hasConceptScore W2041567372C2778917026 @default.
- W2041567372 hasConceptScore W2041567372C2780147359 @default.
- W2041567372 hasConceptScore W2041567372C2994067411 @default.
- W2041567372 hasConceptScore W2041567372C43617362 @default.
- W2041567372 hasConceptScore W2041567372C54355233 @default.
- W2041567372 hasConceptScore W2041567372C552990157 @default.
- W2041567372 hasConceptScore W2041567372C55493867 @default.
- W2041567372 hasConceptScore W2041567372C81089528 @default.
- W2041567372 hasConceptScore W2041567372C86803240 @default.
- W2041567372 hasIssue "9" @default.
- W2041567372 hasLocation W20415673721 @default.
- W2041567372 hasLocation W20415673722 @default.
- W2041567372 hasOpenAccess W2041567372 @default.
- W2041567372 hasPrimaryLocation W20415673721 @default.
- W2041567372 hasRelatedWork W2015271270 @default.
- W2041567372 hasRelatedWork W2026934268 @default.
- W2041567372 hasRelatedWork W2036110227 @default.
- W2041567372 hasRelatedWork W2077747982 @default.
- W2041567372 hasRelatedWork W2342234207 @default.
- W2041567372 hasRelatedWork W2370671565 @default.
- W2041567372 hasRelatedWork W2393893028 @default.
- W2041567372 hasRelatedWork W3192466689 @default.
- W2041567372 hasRelatedWork W4240384084 @default.
- W2041567372 hasRelatedWork W4244255101 @default.
- W2041567372 hasVolume "10" @default.
- W2041567372 isParatext "false" @default.
- W2041567372 isRetracted "false" @default.
- W2041567372 magId "2041567372" @default.
- W2041567372 workType "article" @default.