Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041567385> ?p ?o ?g. }
- W2041567385 endingPage "132" @default.
- W2041567385 startingPage "125" @default.
- W2041567385 abstract "Background Abnormal cell proliferation, which results from deregulation of the cell cycle, is fundamental in tumorigenesis. Objectives To investigate the expression of proliferation markers and cell cycle regulators in a range of T cell lymphoproliferative skin diseases. Methods We studied skin specimens of 51 patients with parapsoriasis (PP), mycosis fungiodes (MF), or lymphomatoid papulosis (LyP). Immunohistochemistry was performed for Ki-67, proliferating cell nuclear antigen (PCNA), minichromosome maintenance protein 7 (MCM7), and p21. Results MF with stage IIB–IV and LyP showed a significantly greater number of Ki-67-positive cells than PP (P = 0.02 and 0.001) and MF I–IIA (P = 0.019 and 0.003), respectively. MCM7 staining revealed significantly higher labeling indices for MF IIB–IV and LyP when compared to PP (P = 0.002 and 0.04) and MF I–IIA (P = 0.0005 and 0.01), respectively. Compared to PP and MF I–IIA, MF IIB–IV was associated with significantly higher labeling indices for PCNA (P = 0.006 and 0.0004). p21 staining was significantly increased in MF IIB–IV and LyP when compared to PP (P = 0.006 and 0.003) and MF I–IIA (P = 0.003). However, p21 staining was all in all very weak. Conclusions Ki-67 and PCNA seem to be useful immunohistological parameters for the correlation with the clinical stage of MF. In the differentiation and prognostication of T cell lymphoproliferative skin disorders, MCM7 may serve as a novel biomarker which is, in contrast to Ki-67 and PCNA, stable throughout the cell cycle." @default.
- W2041567385 created "2016-06-24" @default.
- W2041567385 creator A5006074498 @default.
- W2041567385 creator A5034009185 @default.
- W2041567385 creator A5055279662 @default.
- W2041567385 creator A5064240367 @default.
- W2041567385 creator A5083044979 @default.
- W2041567385 date "2008-02-01" @default.
- W2041567385 modified "2023-10-14" @default.
- W2041567385 title "Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders" @default.
- W2041567385 cites W1835059569 @default.
- W2041567385 cites W1841329429 @default.
- W2041567385 cites W1974208182 @default.
- W2041567385 cites W1985251472 @default.
- W2041567385 cites W1993516105 @default.
- W2041567385 cites W1994198833 @default.
- W2041567385 cites W2001017617 @default.
- W2041567385 cites W2025163738 @default.
- W2041567385 cites W2034796130 @default.
- W2041567385 cites W2041046834 @default.
- W2041567385 cites W2049569276 @default.
- W2041567385 cites W2072444102 @default.
- W2041567385 cites W2083671394 @default.
- W2041567385 cites W2087889033 @default.
- W2041567385 cites W2095030794 @default.
- W2041567385 cites W2096160655 @default.
- W2041567385 cites W2102740981 @default.
- W2041567385 cites W2115354714 @default.
- W2041567385 cites W2145281459 @default.
- W2041567385 cites W2148754918 @default.
- W2041567385 cites W2149194299 @default.
- W2041567385 cites W2150948143 @default.
- W2041567385 cites W2164543039 @default.
- W2041567385 cites W2166551379 @default.
- W2041567385 cites W4231760346 @default.
- W2041567385 cites W4232217815 @default.
- W2041567385 cites W4233762672 @default.
- W2041567385 cites W4254231016 @default.
- W2041567385 cites W2068921313 @default.
- W2041567385 doi "https://doi.org/10.1016/j.jdermsci.2007.07.011" @default.
- W2041567385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17826963" @default.
- W2041567385 hasPublicationYear "2008" @default.
- W2041567385 type Work @default.
- W2041567385 sameAs 2041567385 @default.
- W2041567385 citedByCount "27" @default.
- W2041567385 countsByYear W20415673852012 @default.
- W2041567385 countsByYear W20415673852013 @default.
- W2041567385 countsByYear W20415673852014 @default.
- W2041567385 countsByYear W20415673852015 @default.
- W2041567385 countsByYear W20415673852017 @default.
- W2041567385 countsByYear W20415673852018 @default.
- W2041567385 countsByYear W20415673852020 @default.
- W2041567385 countsByYear W20415673852022 @default.
- W2041567385 countsByYear W20415673852023 @default.
- W2041567385 crossrefType "journal-article" @default.
- W2041567385 hasAuthorship W2041567385A5006074498 @default.
- W2041567385 hasAuthorship W2041567385A5034009185 @default.
- W2041567385 hasAuthorship W2041567385A5055279662 @default.
- W2041567385 hasAuthorship W2041567385A5064240367 @default.
- W2041567385 hasAuthorship W2041567385A5083044979 @default.
- W2041567385 hasConcept C121608353 @default.
- W2041567385 hasConcept C126322002 @default.
- W2041567385 hasConcept C142724271 @default.
- W2041567385 hasConcept C153911025 @default.
- W2041567385 hasConcept C204232928 @default.
- W2041567385 hasConcept C2776995267 @default.
- W2041567385 hasConcept C2777182591 @default.
- W2041567385 hasConcept C2777756187 @default.
- W2041567385 hasConcept C2779338263 @default.
- W2041567385 hasConcept C29537977 @default.
- W2041567385 hasConcept C34688535 @default.
- W2041567385 hasConcept C55493867 @default.
- W2041567385 hasConcept C555283112 @default.
- W2041567385 hasConcept C62112901 @default.
- W2041567385 hasConcept C71924100 @default.
- W2041567385 hasConcept C74864618 @default.
- W2041567385 hasConcept C86803240 @default.
- W2041567385 hasConceptScore W2041567385C121608353 @default.
- W2041567385 hasConceptScore W2041567385C126322002 @default.
- W2041567385 hasConceptScore W2041567385C142724271 @default.
- W2041567385 hasConceptScore W2041567385C153911025 @default.
- W2041567385 hasConceptScore W2041567385C204232928 @default.
- W2041567385 hasConceptScore W2041567385C2776995267 @default.
- W2041567385 hasConceptScore W2041567385C2777182591 @default.
- W2041567385 hasConceptScore W2041567385C2777756187 @default.
- W2041567385 hasConceptScore W2041567385C2779338263 @default.
- W2041567385 hasConceptScore W2041567385C29537977 @default.
- W2041567385 hasConceptScore W2041567385C34688535 @default.
- W2041567385 hasConceptScore W2041567385C55493867 @default.
- W2041567385 hasConceptScore W2041567385C555283112 @default.
- W2041567385 hasConceptScore W2041567385C62112901 @default.
- W2041567385 hasConceptScore W2041567385C71924100 @default.
- W2041567385 hasConceptScore W2041567385C74864618 @default.
- W2041567385 hasConceptScore W2041567385C86803240 @default.
- W2041567385 hasIssue "2" @default.
- W2041567385 hasLocation W20415673851 @default.
- W2041567385 hasLocation W20415673852 @default.
- W2041567385 hasOpenAccess W2041567385 @default.