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- W2041569441 abstract "Significance Angiogenesis, in which new blood vessels form via endothelial cell (EC) sprouting from existing vessels, is critical in embryonic development and multiple disease processes. The intracellular molecular mechanisms governing sprouting angiogenesis remain incompletely understood. We found that transcription factor NF-E2–related factor 2 (Nrf2), well-known for regulating the stress response in multiple pathologic settings, is a critical intracellular regulator in ECs for sprouting angiogenesis in vascular development through delta-like 4 (Dll4)/Notch signaling. Understanding the molecular mechanisms by which Nrf2 regulates angiogenesis could facilitate therapeutic strategies targeting Nrf2 to treat angiogenesis-related diseases, including tumorigenesis, proliferative diabetic retinopathy, atherosclerosis, and ischemic disorders." @default.
- W2041569441 created "2016-06-24" @default.
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- W2041569441 date "2013-09-23" @default.
- W2041569441 modified "2023-10-15" @default.
- W2041569441 title "Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching" @default.
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- W2041569441 doi "https://doi.org/10.1073/pnas.1309276110" @default.
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