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- W2041569707 abstract "We examine the distribution of viral genetic forms and the presence of antiretroviral drug resistance mutations in HIV-1 infections in the Republic of Dagestan, in the North Caucasus area of Russia, where a recent large increase in HIV-1 infections has been documented. Samples were collected from 41 HIV-1-infected individuals from Dagestan, most of them from the cities of Derbent (n = 21) and Mahachkala (n = 18). Thirty six were injecting drug users and five were infected by heterosexual contact. None was on antiretroviral drug treatment. HIV-1 protease and a segment of reverse transcriptase were amplified by RT-PCR from plasma RNA and sequenced, and phylogenetic trees were constructed via maximum likelihood. Forty (97.6%) of 41 samples were of subtype A, former Soviet Union variant (AFSU), of which 27 (67.5%) clustered with the subvariant containing the V77I substitution in protease (V77IPR). Within this cluster, 13 viruses formed a local subcluster, 10 of which were from Derbent. Four viruses clustered with the ASP2 subcluster, recently identified in St. Petersburg, two with a virus from Georgia and one with a virus from Azerbaijan. No mutations associated with antiretroviral drug resistance were detected. The results, therefore, show the relationship of the HIV-1 epidemic in Dagestan with that of other areas of Russia and of neighboring countries, and reveal the spread of the AFSU V77IPR variant in the North Caucasus area." @default.
- W2041569707 created "2016-06-24" @default.
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- W2041569707 date "2010-04-01" @default.
- W2041569707 modified "2023-09-27" @default.
- W2041569707 title "Short Communication: Molecular Epidemiology of HIV Type 1 in the Republic of Dagestan, Russian Federation: Virtually Uniform Circulation of Subtype A, Former Soviet Union Variant, with Predominance of the V77IPR Subvariant" @default.
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- W2041569707 doi "https://doi.org/10.1089/aid.2009.0205" @default.
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