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- W2041578045 abstract "In The Lancet Oncology, Jeffrey Weber and colleagues1 report the first interim analysis of a randomised phase 3 trial comparing nivolumab with chemotherapy in patients with advanced melanoma whose disease had progressed after receiving previous treatment with the anti-CTLA-4 inhibitor ipilimumab, or ipilimumab and a BRAF inhibitor if they had a BRAFV600 mutation. Nivolumab is a fully human IgG4-blocking antibody against the T-cell PD-1 checkpoint protein. The PD-1 receptor negatively regulates T-cell effector mechanisms that restrict immune responses to cancer." @default.
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- W2041578045 date "2015-04-01" @default.
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- W2041578045 title "Nivolumab: another weapon in the growing immunotherapy arsenal" @default.
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- W2041578045 doi "https://doi.org/10.1016/s1470-2045(15)70109-9" @default.
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