Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041584651> ?p ?o ?g. }
- W2041584651 endingPage "583" @default.
- W2041584651 startingPage "579" @default.
- W2041584651 abstract "P-glycoprotein is localized at the apical brush-border membrane of the proximal renal tubule and functions as extruding toxins and xenobiotics out of cells. The difference of P-glycoprotein's function resulted from single nucleotide polymorphisms in MDR1 (multidrug resistance gene encoding for P-gp) and may be the cause of interindividual differences in susceptibility to end-stage renal disease (ESRD). The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in MDR1 between ESRD patients and healthy controls in the Chinese population to determine whether the alteration of the P-gp function is associated with ESRD. Two hundred and eighty-four healthy Chinese controls and 244 Chinese patients with ESRD were involved in this study. Allele specific PCR and polymerase chain reaction-restriction fragment length polymorphism assay were used to determine the genotype MDR1 G1199A and C3435T, respectively. The genotype distribution of 3435CC, 3435CT, and 3435TT were 0.35, 0.50, and 0.15, respectively, in the control group and 0.38, 0.47, and 0.15 in the group with the ESRD patients. No variant allele 1199G>A was found in any of the patients. The value of serum creatinine for genotypes 3435CC, 3435CT, and 3435TT in the ESRD patients were 753.8±276.0 μmol/L, 849.6±342.2 μmol/L, and 987.0±512.0 μmol/L, respectively. The difference between 3435TT and 3435CC reached statistical significance (P<0.05). The low expression of P-glycoprotein was not the etiological factor for the kidney disease, but it may contribute to the progression of ESRD and affect the severity. Chinese people do not carry the 1199G>A variant allele. More studies are needed to clarify the cause and interindividual differences in the susceptibility for the risk of ESRD." @default.
- W2041584651 created "2016-06-24" @default.
- W2041584651 creator A5022706985 @default.
- W2041584651 creator A5050828923 @default.
- W2041584651 creator A5056152061 @default.
- W2041584651 creator A5077423550 @default.
- W2041584651 creator A5077604881 @default.
- W2041584651 creator A5078949281 @default.
- W2041584651 date "2007-04-01" @default.
- W2041584651 modified "2023-10-06" @default.
- W2041584651 title "Effect of MDR1 gene polymorphism on progression of end-stage renal disease" @default.
- W2041584651 cites W1964470226 @default.
- W2041584651 cites W1986871243 @default.
- W2041584651 cites W1999198406 @default.
- W2041584651 cites W2013047801 @default.
- W2041584651 cites W2029510004 @default.
- W2041584651 cites W2058593202 @default.
- W2041584651 cites W2066919313 @default.
- W2041584651 cites W2070332435 @default.
- W2041584651 cites W2078877172 @default.
- W2041584651 cites W2088250393 @default.
- W2041584651 cites W2093105834 @default.
- W2041584651 cites W2096675998 @default.
- W2041584651 cites W2109769259 @default.
- W2041584651 cites W2117944128 @default.
- W2041584651 cites W2123635261 @default.
- W2041584651 cites W2271456353 @default.
- W2041584651 cites W4232195096 @default.
- W2041584651 doi "https://doi.org/10.1111/j.1745-7254.2007.00517.x" @default.
- W2041584651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17376299" @default.
- W2041584651 hasPublicationYear "2007" @default.
- W2041584651 type Work @default.
- W2041584651 sameAs 2041584651 @default.
- W2041584651 citedByCount "10" @default.
- W2041584651 countsByYear W20415846512012 @default.
- W2041584651 countsByYear W20415846512013 @default.
- W2041584651 countsByYear W20415846512014 @default.
- W2041584651 countsByYear W20415846512018 @default.
- W2041584651 countsByYear W20415846512019 @default.
- W2041584651 countsByYear W20415846512021 @default.
- W2041584651 crossrefType "journal-article" @default.
- W2041584651 hasAuthorship W2041584651A5022706985 @default.
- W2041584651 hasAuthorship W2041584651A5050828923 @default.
- W2041584651 hasAuthorship W2041584651A5056152061 @default.
- W2041584651 hasAuthorship W2041584651A5077423550 @default.
- W2041584651 hasAuthorship W2041584651A5077604881 @default.
- W2041584651 hasAuthorship W2041584651A5078949281 @default.
- W2041584651 hasBestOaLocation W20415846511 @default.
- W2041584651 hasConcept C104317684 @default.
- W2041584651 hasConcept C126322002 @default.
- W2041584651 hasConcept C134018914 @default.
- W2041584651 hasConcept C135763542 @default.
- W2041584651 hasConcept C153209595 @default.
- W2041584651 hasConcept C159641895 @default.
- W2041584651 hasConcept C180754005 @default.
- W2041584651 hasConcept C203014093 @default.
- W2041584651 hasConcept C2778653478 @default.
- W2041584651 hasConcept C2779134260 @default.
- W2041584651 hasConcept C2780306776 @default.
- W2041584651 hasConcept C2908647359 @default.
- W2041584651 hasConcept C3019040382 @default.
- W2041584651 hasConcept C37463918 @default.
- W2041584651 hasConcept C54355233 @default.
- W2041584651 hasConcept C71924100 @default.
- W2041584651 hasConcept C86803240 @default.
- W2041584651 hasConcept C90924648 @default.
- W2041584651 hasConcept C99454951 @default.
- W2041584651 hasConceptScore W2041584651C104317684 @default.
- W2041584651 hasConceptScore W2041584651C126322002 @default.
- W2041584651 hasConceptScore W2041584651C134018914 @default.
- W2041584651 hasConceptScore W2041584651C135763542 @default.
- W2041584651 hasConceptScore W2041584651C153209595 @default.
- W2041584651 hasConceptScore W2041584651C159641895 @default.
- W2041584651 hasConceptScore W2041584651C180754005 @default.
- W2041584651 hasConceptScore W2041584651C203014093 @default.
- W2041584651 hasConceptScore W2041584651C2778653478 @default.
- W2041584651 hasConceptScore W2041584651C2779134260 @default.
- W2041584651 hasConceptScore W2041584651C2780306776 @default.
- W2041584651 hasConceptScore W2041584651C2908647359 @default.
- W2041584651 hasConceptScore W2041584651C3019040382 @default.
- W2041584651 hasConceptScore W2041584651C37463918 @default.
- W2041584651 hasConceptScore W2041584651C54355233 @default.
- W2041584651 hasConceptScore W2041584651C71924100 @default.
- W2041584651 hasConceptScore W2041584651C86803240 @default.
- W2041584651 hasConceptScore W2041584651C90924648 @default.
- W2041584651 hasConceptScore W2041584651C99454951 @default.
- W2041584651 hasIssue "4" @default.
- W2041584651 hasLocation W20415846511 @default.
- W2041584651 hasLocation W20415846512 @default.
- W2041584651 hasOpenAccess W2041584651 @default.
- W2041584651 hasPrimaryLocation W20415846511 @default.
- W2041584651 hasRelatedWork W2008023461 @default.
- W2041584651 hasRelatedWork W2008843816 @default.
- W2041584651 hasRelatedWork W2161808406 @default.
- W2041584651 hasRelatedWork W2348076134 @default.
- W2041584651 hasRelatedWork W2355028327 @default.
- W2041584651 hasRelatedWork W2358154819 @default.
- W2041584651 hasRelatedWork W2388486920 @default.