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• W2041604359 abstract "We studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Alzheimer type dementia (ATD) compared with controls. In ATD patients, concentrations of total 5-HT, tryptophan, 5-hydroxytryptophan (5-HTP), melatonin, kynurenine, and 3-hydroxykynurenine decreased significantly. The rate of concentration of tryptophan metabolites to that of tryptophan was significantly reduced for total 5-HT and 3-hydroxykynurenine only. The 5-hydroxyindoleacetic acid (5-HIAA)5-HT ratio was significantly larger in ATD patients than in controls. The greater reduction in the 3-hydroxykynurenine concentration (81% vs. controls) than in the total 5-HT concentration (51% vs. controls) suggests that the metabolism of tryptophan to 5-HT and 3-hydroxykynurenine is in favor of 5-HT." @default.
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• W2041604359 date "1992-07-01" @default.
• W2041604359 modified "2023-10-15" @default.
• W2041604359 title "Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia" @default.
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• W2041604359 doi "https://doi.org/10.1016/0304-3940(92)90322-x" @default.
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