FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041609594> ?p ?o ?g. }

• W2041609594 endingPage "400" @default.
• W2041609594 startingPage "382" @default.
• W2041609594 abstract "Intraarticular injection of recombinant human interleukin-1 (IL-1) in rats resulted in varying degrees of inflammatory changes depending on the site and frequency of injections. (i) Much lower amounts of IL-1 were required to elicit an inflammatory response in the ankle joints (15-3000 ng) than the knee joints (90-150 micrograms). (ii) The inflammatory response was much greater if IL-1 was administered in multiple doses as compared to a single dose injection. One day after a single injection of IL-1 (90-150 micrograms), knee joints exhibited a mild increase in volume as a consequence of edema, but at the end of 1 week, no discernible change in volume was observed. However, when the same total amount of IL-1 was injected in three doses, there was a dramatic increase in joint volume at the end of 1 week that persisted for at least 3 weeks. The increase was dose dependent. (iii) The inflammatory response was dependent on the age/weight of the rats: the older the animals the greater the response. (iv) Under conditions where IL-1 induced inflammatory changes in knee joints, recombinant tumor necrosis factor failed to induce any significant response. (v) Histological examination of the knee joints revealed distinct differences in the pathological response to the two different protocols of IL-1 administration in the knee joints. The animals injected with a single dose of IL-1 showed a mild and transient inflammation that was resolved by 2 weeks postinjection, but exhibited degenerative changes associated with focal loss of chondrocytes and proteoglycan of the knee joint cartilage, which became progressively severe. The knee joints of animals given three injections of IL-1 showed evidence of marked acute synovitis, fibroplasia, loss of proteoglycan and chondrocytes, resorption of subchondral bone, and transition of hematopoeitic marrow cells into cells of mesenchymal morphology. (vi) Examination of proteoglycan synthesis by cartilage of IL-1-injected rats revealed that within 1 day after injection, a dramatic reduction in synthesis occurred which persisted for at least 2 weeks. These studies suggest that intraarticular injection of IL-1 provides a useful rodent model for the investigation of pathological changes occurring within a localized joint as a result of acute and chronic inflammatory stimuli. Relevant aspects of the pathology of joint erosion can be demonstrated depending on the frequency of IL-1 injection." @default.
• W2041609594 created "2016-06-24" @default.
• W2041609594 creator A5026634138 @default.
• W2041609594 creator A5063151497 @default.
• W2041609594 creator A5063835499 @default.
• W2041609594 creator A5071194529 @default.
• W2041609594 date "1990-06-01" @default.
• W2041609594 modified "2023-10-16" @default.
• W2041609594 title "Arthritis induced by interleukin-1 is dependent on the site and frequency of intraarticular injection" @default.
• W2041609594 cites W1606989410 @default.
• W2041609594 cites W1848552725 @default.
• W2041609594 cites W1971890827 @default.
• W2041609594 cites W1979048956 @default.
• W2041609594 cites W1981163610 @default.
• W2041609594 cites W1989045284 @default.
• W2041609594 cites W1989943230 @default.
• W2041609594 cites W1991636897 @default.
• W2041609594 cites W1997638718 @default.
• W2041609594 cites W1998868640 @default.
• W2041609594 cites W2002050807 @default.
• W2041609594 cites W2003576401 @default.
• W2041609594 cites W2011234068 @default.
• W2041609594 cites W2015157953 @default.
• W2041609594 cites W2016710605 @default.
• W2041609594 cites W2025563892 @default.
• W2041609594 cites W2029165602 @default.
• W2041609594 cites W2046015503 @default.
• W2041609594 cites W2048040148 @default.
• W2041609594 cites W2051585460 @default.
• W2041609594 cites W2056406997 @default.
• W2041609594 cites W2073977304 @default.
• W2041609594 cites W2076291910 @default.
• W2041609594 cites W2083911989 @default.
• W2041609594 cites W2084462963 @default.
• W2041609594 cites W2094341759 @default.
• W2041609594 cites W2123730940 @default.
• W2041609594 cites W2131115069 @default.
• W2041609594 cites W2156448948 @default.
• W2041609594 cites W2167088687 @default.
• W2041609594 cites W2168894946 @default.
• W2041609594 cites W2169274110 @default.
• W2041609594 cites W2335815491 @default.
• W2041609594 cites W4206163632 @default.
• W2041609594 doi "https://doi.org/10.1016/0090-1229(90)90126-b" @default.
• W2041609594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2340648" @default.
• W2041609594 hasPublicationYear "1990" @default.
• W2041609594 type Work @default.
• W2041609594 sameAs 2041609594 @default.
• W2041609594 citedByCount "57" @default.
• W2041609594 countsByYear W20416095942012 @default.
• W2041609594 countsByYear W20416095942017 @default.
• W2041609594 countsByYear W20416095942018 @default.
• W2041609594 countsByYear W20416095942022 @default.
• W2041609594 countsByYear W20416095942023 @default.
• W2041609594 crossrefType "journal-article" @default.
• W2041609594 hasAuthorship W2041609594A5026634138 @default.
• W2041609594 hasAuthorship W2041609594A5063151497 @default.
• W2041609594 hasAuthorship W2041609594A5063835499 @default.
• W2041609594 hasAuthorship W2041609594A5071194529 @default.
• W2041609594 hasConcept C126322002 @default.
• W2041609594 hasConcept C134018914 @default.
• W2041609594 hasConcept C141071460 @default.
• W2041609594 hasConcept C142724271 @default.
• W2041609594 hasConcept C17991360 @default.
• W2041609594 hasConcept C2776914184 @default.
• W2041609594 hasConcept C2777077863 @default.
• W2041609594 hasConcept C2778640784 @default.
• W2041609594 hasConcept C2778690821 @default.
• W2041609594 hasConcept C2780886150 @default.
• W2041609594 hasConcept C2908736133 @default.
• W2041609594 hasConcept C3020196126 @default.
• W2041609594 hasConcept C71924100 @default.
• W2041609594 hasConcept C74172505 @default.
• W2041609594 hasConceptScore W2041609594C126322002 @default.
• W2041609594 hasConceptScore W2041609594C134018914 @default.
• W2041609594 hasConceptScore W2041609594C141071460 @default.
• W2041609594 hasConceptScore W2041609594C142724271 @default.
• W2041609594 hasConceptScore W2041609594C17991360 @default.
• W2041609594 hasConceptScore W2041609594C2776914184 @default.
• W2041609594 hasConceptScore W2041609594C2777077863 @default.
• W2041609594 hasConceptScore W2041609594C2778640784 @default.
• W2041609594 hasConceptScore W2041609594C2778690821 @default.
• W2041609594 hasConceptScore W2041609594C2780886150 @default.
• W2041609594 hasConceptScore W2041609594C2908736133 @default.
• W2041609594 hasConceptScore W2041609594C3020196126 @default.
• W2041609594 hasConceptScore W2041609594C71924100 @default.
• W2041609594 hasConceptScore W2041609594C74172505 @default.
• W2041609594 hasIssue "3" @default.
• W2041609594 hasLocation W20416095941 @default.
• W2041609594 hasLocation W20416095942 @default.
• W2041609594 hasOpenAccess W2041609594 @default.
• W2041609594 hasPrimaryLocation W20416095941 @default.
• W2041609594 hasRelatedWork W115674540 @default.
• W2041609594 hasRelatedWork W1977918131 @default.
• W2041609594 hasRelatedWork W1990717759 @default.
• W2041609594 hasRelatedWork W2034985166 @default.
• W2041609594 hasRelatedWork W2262573558 @default.
• W2041609594 hasRelatedWork W2409296823 @default.

• next