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• W2041609821 abstract "This report describes the investigation of the pathogenesis of an unusual sequel of reovirus encephalitis in suckling rats. Intracerebral inoculation of reovirus types 1, 2, and 3 into suckling rats induced, in addition to viral cytoplasmic inclusions, distinctive intranuclear bodies corresponding most closely to those designated by Cowdry (1934) as type B inclusions. The latter were seen in cells free of reovirus inclusions and unlike the conventional reactions to these viruses, were readily observed in weanlings, were unassociated with inflammatory features, and persisted for extended periods without cytolytic effects. To test the hypothesis that another viral agent was responsible for production of these nuclear changes, attempts were made to induce this change by inoculation of tissue preparations obtained from infected animals beyond the period of active reovirus encephalitis. These were uniformly negative. Furthermore, strains of reovirus from various sources all induced this nuclear change. Electron microscopic studies of the choroid plexus yielded no evidence of a second virus but instead demonstrated that the inclusions were composed of granular aggregates, sometimes enclosed in lamellar membranes, characteristic of the structures called nuclear bodies. These studies expand the perspectives of the nature and pathogenesis of this cellular lesion and provide an optical indicator which facilitates its identification and study. They suggest that the well-known Cowdry B inclusion has as its electron microscopic counterpart, the nuclear body." @default.
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• W2041609821 date "1975-10-01" @default.
• W2041609821 modified "2023-10-17" @default.
• W2041609821 title "Identity of cowdry type B inclusions and nuclear bodies: Observations in reovirus encephalitis" @default.
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• W2041609821 doi "https://doi.org/10.1016/0014-4800(75)90021-0" @default.
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