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• W2041625900 endingPage "e1002281" @default.
• W2041625900 startingPage "e1002281" @default.
• W2041625900 abstract "The liver removes quickly the great bulk of virus circulating in blood, leaving only a small fraction to infect the host, in a manner characteristic of each virus. The scavenger cells of the liver sinusoids are implicated, but the mechanism is entirely unknown. Here we show, borrowing a mouse model of adenovirus clearance, that nearly all infused adenovirus is cleared by the liver sinusoidal endothelial cell (LSEC). Using refined immunofluorescence microscopy techniques for distinguishing macrophages and endothelial cells in fixed liver, and identifying virus by two distinct physicochemical methods, we localized adenovirus 1 minute after infusion mainly to the LSEC (∼90%), finding ∼10% with Kupffer cells (KC) and none with hepatocytes. Electron microscopy confirmed our results. In contrast with much prior work claiming the main scavenger to be the KC, our results locate the clearance mechanism to the LSEC and identify this cell as a key site of antiviral activity." @default.
• W2041625900 created "2016-06-24" @default.
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• W2041625900 date "2011-09-29" @default.
• W2041625900 modified "2023-10-15" @default.
• W2041625900 title "Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium" @default.
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• W2041625900 doi "https://doi.org/10.1371/journal.ppat.1002281" @default.
• W2041625900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3182912" @default.
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• W2041625900 hasPublicationYear "2011" @default.
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