FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041640706> ?p ?o ?g. }

• W2041640706 endingPage "939" @default.
• W2041640706 startingPage "933" @default.
• W2041640706 abstract "Polymorphisms in cytochrome P450 (CYP450) genes contribute to interindividual differences in the metabolism of xenobiotic chemicals, including the vast majority of drugs, and may lead to toxicity and adverse drug reactions. Studies on these polymorphisms in research and diagnostic settings typically involve large-scale genotyping and hence require high-throughput assays.We used the previously developed solid-phase capture-single-base extension (SPC-SBE) approach for concurrent analysis of 40 single-nucleotide polymorphisms (SNPs) of CYP2C9 and 50 SNPs of CYP2A13, both genes belonging to the CYP450 family. Desired SNP-containing regions for each gene were amplified in a single-step multiplex PCR. We designed a library of primers to anneal immediately upstream of the selected SNPs and extended it with biotinylated terminators using PCR products as templates. Biotinylated extension products were isolated by affinity purification and analyzed with MALDI-TOF mass spectrometry to determine SNP genotypes.We analyzed 11 samples for CYP2C9 and 14 samples for CYP2A13 with unambiguous detection of SNPs in all samples. Many samples showed a high occurrence of heterozygotes for both genes, with as many as 10 of 50 SNPs appearing as heterozygotes in 1 sample genotyped for CYP2A13.The SPC-SBE method provides an efficient means for genotyping SNPs from the CYP450 family. This approach is suitable for automation and can be extended to other genotyping applications." @default.
• W2041640706 created "2016-06-24" @default.
• W2041640706 creator A5005912924 @default.
• W2041640706 creator A5025571461 @default.
• W2041640706 creator A5090220697 @default.
• W2041640706 date "2007-05-01" @default.
• W2041640706 modified "2023-10-14" @default.
• W2041640706 title "Multiplex Genotyping of Cytochrome P450 Single-Nucleotide Polymorphisms by Use of MALDI-TOF Mass Spectrometry" @default.
• W2041640706 cites W1572719294 @default.
• W2041640706 cites W1965789653 @default.
• W2041640706 cites W1967619341 @default.
• W2041640706 cites W1967970335 @default.
• W2041640706 cites W1971034474 @default.
• W2041640706 cites W1975191556 @default.
• W2041640706 cites W1996810652 @default.
• W2041640706 cites W1998634450 @default.
• W2041640706 cites W1999790144 @default.
• W2041640706 cites W2010725469 @default.
• W2041640706 cites W2036040400 @default.
• W2041640706 cites W2038949659 @default.
• W2041640706 cites W2055043387 @default.
• W2041640706 cites W2056859207 @default.
• W2041640706 cites W2062723602 @default.
• W2041640706 cites W2068367944 @default.
• W2041640706 cites W2074169605 @default.
• W2041640706 cites W2086766148 @default.
• W2041640706 cites W2090652275 @default.
• W2041640706 cites W2096561572 @default.
• W2041640706 cites W2111838693 @default.
• W2041640706 cites W2117240964 @default.
• W2041640706 cites W2117282939 @default.
• W2041640706 cites W2122732537 @default.
• W2041640706 cites W2133194323 @default.
• W2041640706 cites W2138467859 @default.
• W2041640706 cites W2161780024 @default.
• W2041640706 cites W2164705071 @default.
• W2041640706 cites W2407967556 @default.
• W2041640706 cites W4251079740 @default.
• W2041640706 doi "https://doi.org/10.1373/clinchem.2006.080739" @default.
• W2041640706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17384008" @default.
• W2041640706 hasPublicationYear "2007" @default.
• W2041640706 type Work @default.
• W2041640706 sameAs 2041640706 @default.
• W2041640706 citedByCount "23" @default.
• W2041640706 countsByYear W20416407062012 @default.
• W2041640706 countsByYear W20416407062013 @default.
• W2041640706 countsByYear W20416407062014 @default.
• W2041640706 countsByYear W20416407062016 @default.
• W2041640706 countsByYear W20416407062020 @default.
• W2041640706 crossrefType "journal-article" @default.
• W2041640706 hasAuthorship W2041640706A5005912924 @default.
• W2041640706 hasAuthorship W2041640706A5025571461 @default.
• W2041640706 hasAuthorship W2041640706A5090220697 @default.
• W2041640706 hasBestOaLocation W20416407061 @default.
• W2041640706 hasConcept C104317684 @default.
• W2041640706 hasConcept C135763542 @default.
• W2041640706 hasConcept C153209595 @default.
• W2041640706 hasConcept C153911025 @default.
• W2041640706 hasConcept C163691529 @default.
• W2041640706 hasConcept C194857396 @default.
• W2041640706 hasConcept C2781188995 @default.
• W2041640706 hasConcept C31467283 @default.
• W2041640706 hasConcept C512185932 @default.
• W2041640706 hasConcept C54355233 @default.
• W2041640706 hasConcept C70721500 @default.
• W2041640706 hasConcept C86803240 @default.
• W2041640706 hasConceptScore W2041640706C104317684 @default.
• W2041640706 hasConceptScore W2041640706C135763542 @default.
• W2041640706 hasConceptScore W2041640706C153209595 @default.
• W2041640706 hasConceptScore W2041640706C153911025 @default.
• W2041640706 hasConceptScore W2041640706C163691529 @default.
• W2041640706 hasConceptScore W2041640706C194857396 @default.
• W2041640706 hasConceptScore W2041640706C2781188995 @default.
• W2041640706 hasConceptScore W2041640706C31467283 @default.
• W2041640706 hasConceptScore W2041640706C512185932 @default.
• W2041640706 hasConceptScore W2041640706C54355233 @default.
• W2041640706 hasConceptScore W2041640706C70721500 @default.
• W2041640706 hasConceptScore W2041640706C86803240 @default.
• W2041640706 hasFunder F4320337361 @default.
• W2041640706 hasIssue "5" @default.
• W2041640706 hasLocation W20416407061 @default.
• W2041640706 hasLocation W20416407062 @default.
• W2041640706 hasOpenAccess W2041640706 @default.
• W2041640706 hasPrimaryLocation W20416407061 @default.
• W2041640706 hasRelatedWork W169191484 @default.
• W2041640706 hasRelatedWork W1908241373 @default.
• W2041640706 hasRelatedWork W1964329986 @default.
• W2041640706 hasRelatedWork W1999510862 @default.
• W2041640706 hasRelatedWork W2009782791 @default.
• W2041640706 hasRelatedWork W2076413385 @default.
• W2041640706 hasRelatedWork W2106636268 @default.
• W2041640706 hasRelatedWork W2120512069 @default.
• W2041640706 hasRelatedWork W2126962132 @default.
• W2041640706 hasRelatedWork W2164332050 @default.
• W2041640706 hasVolume "53" @default.
• W2041640706 isParatext "false" @default.
• W2041640706 isRetracted "false" @default.
• W2041640706 magId "2041640706" @default.

• next