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- W2041653126 abstract "gamma-Glutamylcysteinylethyl ester (gamma-GCE) increases reduced glutathione (GSH) levels in GSH-depleted rat hepatocytes. Because glycine, a constituent of GSH, exists at 0.3 to 0.4 mM in rat plasma, we examined the influence of glycine added to the medium on the action of gamma-GCE to increase GSH levels in the rat hepatocytes. Glycine (0.2-0.8 mM) dose-dependently enhanced gamma-GCE-mediated increase in intracellular GSH levels with an increase in intracellular gamma-GCE levels. These results indicate that exogenous glycine facilitates gamma-GCE-mediated increase in intracellular GSH levels in rat hepatocytes possibly by enhancing the uptake of gamma-GCE into the cells." @default.
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- W2041653126 date "1997-08-01" @default.
- W2041653126 modified "2023-09-27" @default.
- W2041653126 title "Glycine facilitates γ-glutamylcysteinylethyl ester-mediated increase in liver glutathione level" @default.
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- W2041653126 doi "https://doi.org/10.1016/s0014-2999(97)01130-8" @default.
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