Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041670467> ?p ?o ?g. }
- W2041670467 endingPage "1258" @default.
- W2041670467 startingPage "1249" @default.
- W2041670467 abstract "Abstract The regulation of CD4 T-cell numbers during an immune response should take account of the amount of antigen (Ag), the initial frequency of Ag-specific T cells, the mix of naive versus experienced cells, and (ideally) the diversity of the repertoire. Here we describe a novel mechanism of T-cell regulation that potentially deals with all of these parameters. We found that CD4 T cells establish a negative feedback loop by capturing their cognate major histocompatibility class (MHC)/peptide complexes from Ag-presenting cells and presenting them to Ag-experienced CD4 T cells, thereby inhibiting their recruitment into the response while allowing recruitment of naive T cells. The inhibition is Ag specific, begins at day 2 (long before Ag disappearance), and cannot be overcome by providing new Ag-loaded dendritic cells. In this way, CD4 T-cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety." @default.
- W2041670467 created "2016-06-24" @default.
- W2041670467 creator A5003465170 @default.
- W2041670467 creator A5009626082 @default.
- W2041670467 creator A5026436234 @default.
- W2041670467 creator A5029144785 @default.
- W2041670467 creator A5051030997 @default.
- W2041670467 creator A5062894983 @default.
- W2041670467 creator A5066882928 @default.
- W2041670467 creator A5074905090 @default.
- W2041670467 creator A5089114288 @default.
- W2041670467 date "2008-08-15" @default.
- W2041670467 modified "2023-10-18" @default.
- W2041670467 title "Antigen-specific T-T interactions regulate CD4 T-cell expansion" @default.
- W2041670467 cites W1481671615 @default.
- W2041670467 cites W1482928030 @default.
- W2041670467 cites W1488377901 @default.
- W2041670467 cites W1507800008 @default.
- W2041670467 cites W1521515468 @default.
- W2041670467 cites W1530044612 @default.
- W2041670467 cites W1567391391 @default.
- W2041670467 cites W1669165205 @default.
- W2041670467 cites W1831732289 @default.
- W2041670467 cites W1931750338 @default.
- W2041670467 cites W1971886057 @default.
- W2041670467 cites W1985859196 @default.
- W2041670467 cites W1989808086 @default.
- W2041670467 cites W1994453856 @default.
- W2041670467 cites W1996483176 @default.
- W2041670467 cites W2000061036 @default.
- W2041670467 cites W2004028083 @default.
- W2041670467 cites W2012163630 @default.
- W2041670467 cites W2013356033 @default.
- W2041670467 cites W2022306056 @default.
- W2041670467 cites W2041083837 @default.
- W2041670467 cites W2041658172 @default.
- W2041670467 cites W2042269543 @default.
- W2041670467 cites W2042519375 @default.
- W2041670467 cites W2045893773 @default.
- W2041670467 cites W2046721624 @default.
- W2041670467 cites W2055495862 @default.
- W2041670467 cites W2061184047 @default.
- W2041670467 cites W2068793640 @default.
- W2041670467 cites W2071969437 @default.
- W2041670467 cites W2076121010 @default.
- W2041670467 cites W2081843353 @default.
- W2041670467 cites W2094854776 @default.
- W2041670467 cites W2108909957 @default.
- W2041670467 cites W2110252036 @default.
- W2041670467 cites W2113148417 @default.
- W2041670467 cites W2119900303 @default.
- W2041670467 cites W2127404676 @default.
- W2041670467 cites W2130040879 @default.
- W2041670467 cites W2131063794 @default.
- W2041670467 cites W2131905612 @default.
- W2041670467 cites W2137299530 @default.
- W2041670467 cites W2137384756 @default.
- W2041670467 cites W2149123553 @default.
- W2041670467 cites W2149764521 @default.
- W2041670467 cites W2158670001 @default.
- W2041670467 cites W2162543584 @default.
- W2041670467 cites W2163351493 @default.
- W2041670467 cites W2170904230 @default.
- W2041670467 doi "https://doi.org/10.1182/blood-2007-09-114389" @default.
- W2041670467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2515122" @default.
- W2041670467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18539897" @default.
- W2041670467 hasPublicationYear "2008" @default.
- W2041670467 type Work @default.
- W2041670467 sameAs 2041670467 @default.
- W2041670467 citedByCount "60" @default.
- W2041670467 countsByYear W20416704672012 @default.
- W2041670467 countsByYear W20416704672013 @default.
- W2041670467 countsByYear W20416704672014 @default.
- W2041670467 countsByYear W20416704672015 @default.
- W2041670467 countsByYear W20416704672016 @default.
- W2041670467 countsByYear W20416704672018 @default.
- W2041670467 countsByYear W20416704672019 @default.
- W2041670467 countsByYear W20416704672020 @default.
- W2041670467 countsByYear W20416704672021 @default.
- W2041670467 countsByYear W20416704672022 @default.
- W2041670467 countsByYear W20416704672023 @default.
- W2041670467 crossrefType "journal-article" @default.
- W2041670467 hasAuthorship W2041670467A5003465170 @default.
- W2041670467 hasAuthorship W2041670467A5009626082 @default.
- W2041670467 hasAuthorship W2041670467A5026436234 @default.
- W2041670467 hasAuthorship W2041670467A5029144785 @default.
- W2041670467 hasAuthorship W2041670467A5051030997 @default.
- W2041670467 hasAuthorship W2041670467A5062894983 @default.
- W2041670467 hasAuthorship W2041670467A5066882928 @default.
- W2041670467 hasAuthorship W2041670467A5074905090 @default.
- W2041670467 hasAuthorship W2041670467A5089114288 @default.
- W2041670467 hasBestOaLocation W20416704672 @default.
- W2041670467 hasConcept C121332964 @default.
- W2041670467 hasConcept C147483822 @default.
- W2041670467 hasConcept C153911025 @default.
- W2041670467 hasConcept C154317977 @default.
- W2041670467 hasConcept C202751555 @default.
- W2041670467 hasConcept C203014093 @default.