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- W2041689952 abstract "The rhizoid of Laminaria japonica is widely used in Chinese medicine as a treatment for diabetes. Therefore, a bioactivity-tailored isolation and detailed chemical characterization was used to identify the antidiabetes compounds found in the L. japonica rhizoid. Liquid chromatography/mass spectrometry (LC/MS), proton NMR and carbon NMR spectra analyses demonstrated that the active compound was butyl-isobutyl-phthalate (BIP). BIP demonstrated a significant concentration-dependent, non-competitive inhibitory activity against α-glucosidase in vitro, with an IC50 of 38 μm. In vivo, the ethyl acetate fraction (EAF) and purified BIP displayed a significant hypoglycemic effect in streptozocin-induced diabetic mice. The present study indicates BIP could be considered as an α-glucosidase inhibitor and developed as an important antidiabetes agent for type II diabetes therapy. Copyright © 2010 John Wiley & Sons, Ltd." @default.
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- W2041689952 date "2010-10-28" @default.
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- W2041689952 title "α-glucosidase inhibition and the <i>in vivo</i> hypoglycemic effect of butyl-isobutyl-phthalate derived from the <i>Laminaria japonica</i> rhizoid" @default.
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- W2041689952 doi "https://doi.org/10.1002/ptr.3139" @default.
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