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- W2041696010 abstract "Synthetic glycoclusters and their related biological applications have stimulated increasing interest over the last decade. As a prerequisite to discovering active and selective therapeuticals, the development of multivalent glycoconjugates with diverse topologies is faced with inherent synthetic and structural characterisation difficulties. Here we describe a new series of molecularly-defined glycoclusters that were synthesized in a controlled manner using a robust and versatile divergent protocol. Starting from a Regioselectively Addressable Functionalized Template (RAFT) carrier, either a polylysine dendritic framework or a second RAFT, then 16 copies of βGal, αMan, βLac or cancer-related Thomsen-Freidenreich (αTF) antigen were successively conjugated within the same molecule using oxime chemistry. We thus obtained a new generation of dendri-RAFTs glycoclusters with high glycosidic density and variable spatial organizations. These compounds displaying 16 endgroups were unambiguously characterized by NMR spectroscopy and mass spectrometry. Further biological assays between a model lectin from Canavalia ensiformis (ConA) and mannosylated glycoclusters revealed a higher inhibition potency than the tetravalent counterpart, in particular for the hexadecavalent polylysine skeleton. Together with the efficiency of the synthetic and characterisation processes, this preliminary biological study provided clear evidence of promising properties that make the second generation of cyclopeptide-based glycoclusters attractive for biomedical applications." @default.
- W2041696010 created "2016-06-24" @default.
- W2041696010 creator A5000847014 @default.
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- W2041696010 creator A5075602639 @default.
- W2041696010 date "2011-01-01" @default.
- W2041696010 modified "2023-10-17" @default.
- W2041696010 title "Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters" @default.
- W2041696010 cites W1512847790 @default.
- W2041696010 cites W1965650017 @default.
- W2041696010 cites W1966081349 @default.
- W2041696010 cites W1972937663 @default.
- W2041696010 cites W1974322085 @default.
- W2041696010 cites W1974772173 @default.
- W2041696010 cites W1980678692 @default.
- W2041696010 cites W1980874128 @default.
- W2041696010 cites W1982047046 @default.
- W2041696010 cites W1982143526 @default.
- W2041696010 cites W1982264696 @default.
- W2041696010 cites W1990606491 @default.
- W2041696010 cites W1991333674 @default.
- W2041696010 cites W1992888087 @default.
- W2041696010 cites W1993771099 @default.
- W2041696010 cites W1994023869 @default.
- W2041696010 cites W1995045174 @default.
- W2041696010 cites W1998985805 @default.
- W2041696010 cites W2001439847 @default.
- W2041696010 cites W2003587332 @default.
- W2041696010 cites W2003802570 @default.
- W2041696010 cites W2005257092 @default.
- W2041696010 cites W2005920318 @default.
- W2041696010 cites W2006214486 @default.
- W2041696010 cites W2006798685 @default.
- W2041696010 cites W2010621614 @default.
- W2041696010 cites W2013654351 @default.
- W2041696010 cites W2018470991 @default.
- W2041696010 cites W2019936739 @default.
- W2041696010 cites W2020737596 @default.
- W2041696010 cites W2022086649 @default.
- W2041696010 cites W2023485219 @default.
- W2041696010 cites W2024846013 @default.
- W2041696010 cites W2026157780 @default.
- W2041696010 cites W2029661897 @default.
- W2041696010 cites W2030713521 @default.
- W2041696010 cites W2031278473 @default.
- W2041696010 cites W2034080337 @default.
- W2041696010 cites W2034194669 @default.
- W2041696010 cites W2035096211 @default.
- W2041696010 cites W2035151448 @default.
- W2041696010 cites W2036558034 @default.
- W2041696010 cites W2042127800 @default.
- W2041696010 cites W2047878089 @default.
- W2041696010 cites W2049617777 @default.
- W2041696010 cites W2050626445 @default.
- W2041696010 cites W2052020081 @default.
- W2041696010 cites W2056042508 @default.
- W2041696010 cites W2056491325 @default.
- W2041696010 cites W2059375062 @default.
- W2041696010 cites W2065023769 @default.
- W2041696010 cites W2074770586 @default.
- W2041696010 cites W2076595001 @default.
- W2041696010 cites W2076755375 @default.
- W2041696010 cites W2080655915 @default.
- W2041696010 cites W2083260383 @default.
- W2041696010 cites W2087345192 @default.
- W2041696010 cites W2090309798 @default.
- W2041696010 cites W2090744814 @default.
- W2041696010 cites W2094490113 @default.
- W2041696010 cites W2102876461 @default.
- W2041696010 cites W2116346327 @default.
- W2041696010 cites W2121191797 @default.
- W2041696010 cites W2124298469 @default.
- W2041696010 cites W2125220293 @default.
- W2041696010 cites W2126818937 @default.
- W2041696010 cites W2143714577 @default.
- W2041696010 cites W2145772823 @default.
- W2041696010 cites W2146039642 @default.
- W2041696010 cites W2170527625 @default.
- W2041696010 cites W2171784165 @default.
- W2041696010 cites W2342293295 @default.
- W2041696010 cites W2950532803 @default.
- W2041696010 cites W2950856726 @default.
- W2041696010 cites W2951073036 @default.
- W2041696010 cites W2952494468 @default.
- W2041696010 cites W2953019130 @default.
- W2041696010 cites W41034939 @default.
- W2041696010 cites W4211067069 @default.
- W2041696010 cites W4211247608 @default.
- W2041696010 cites W4251775387 @default.
- W2041696010 doi "https://doi.org/10.1039/c0ob00772b" @default.
- W2041696010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21221455" @default.
- W2041696010 hasPublicationYear "2011" @default.