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• W2041696588 endingPage "1995" @default.
• W2041696588 startingPage "1990" @default.
• W2041696588 abstract "RU-486 (17 beta-hydroxy-4-dimethylaminophenyl-17-alpha-propenyl estrone 4,9 diene-3-one; mifepristone) is suggested to act by binding to progesterone and glucocorticoid receptors. Based on its chemical nature, we anticipated that RU-486 may have potent antioxidant properties. We used the oxidation of LDL as our model system. RU-486 and a similar compound, onapristone, at 1-5-microM concentrations, decreased the formation of oxidized LDL. LDL isolated from plasma of subjects who were orally supplemented with RU-486 was resistant to oxidation, as compared to LDL isolated from control plasma. The antioxidant effect of RU-486 appears to reside in the dimethylaminophenyl side chain moiety. Reduction of the A-ring of the steroid molecule had no effect on its antioxidant property. Analogs of RU-486 which lack the dimethylaminophenyl group, were without antioxidant activity. Levonorgestrel, which lacks the dimethylaminophenyl group failed to inhibit the oxidation of LDL even at 100-microM levels. In contrast, ethinylestradiol and estradiol which do not possess the dimethylamino group, were able to inhibit the oxidation of LDL by virtue of their phenolic steroid A ring. Thus RU-486, with its long half life, high plasma concentrations, association with lipoproteins, and ability to readily enter the cell may have additional intra- and extra-cellular antioxidant effects." @default.
• W2041696588 created "2016-06-24" @default.
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• W2041696588 date "1994-11-01" @default.
• W2041696588 modified "2023-09-27" @default.
• W2041696588 title "Antioxidant: a new role for RU-486 and related compounds." @default.
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• W2041696588 doi "https://doi.org/10.1172/jci117551" @default.
• W2041696588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/294624" @default.
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• W2041696588 hasPublicationYear "1994" @default.
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