Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041704786> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2041704786 endingPage "4452" @default.
- W2041704786 startingPage "4443" @default.
- W2041704786 abstract "Chalcones with 2',3',4'-trimethoxy, 2',4'-dimethoxy, 4'-methoxy, 4'-ethoxy, 2',4'-dihydroxy, and 4'-hydroxy groups on ring B were synthesized and evaluated in vitro against Plasmodium falciparum (K1) in a [3H] hypoxanthine uptake assay. The other ring A was quinoline, pyridine, naphthalene, or phenyl rings with electron-donating or electron-withdrawing substituents of varying lipophilicities. Trimethoxy 6 and 27, dimethoxy 7, 8, 29, and methoxy 31 analogues had good in vitro activities (IC(50) < 5 microM). 3-Quinolinyl ring A derivatives were well represented among the active compounds. Hydroxylated chalcones were less active than the corresponding alkoxylated analogues. When evaluated in vivo, 8 and 208 were comparable to chloroquine in extending the lifespan of infected mice. Multivariate data analysis showed that in vitro activity was mainly determined by the properties of ring B. Quantitative structure-activity relationship models with satisfactory predictive ability were obtained for various B ring chalcones using projections to latent structures. A model with good predictability was proposed for 19 active chalcones. Size and hydrophobicity were identified as critical parameters." @default.
- W2041704786 created "2016-06-24" @default.
- W2041704786 creator A5008476416 @default.
- W2041704786 creator A5029259484 @default.
- W2041704786 creator A5038348164 @default.
- W2041704786 date "2001-10-30" @default.
- W2041704786 modified "2023-10-11" @default.
- W2041704786 title "Antimalarial Alkoxylated and Hydroxylated Chalones: Structure−Activity Relationship Analysis" @default.
- W2041704786 cites W1546287954 @default.
- W2041704786 cites W1975135031 @default.
- W2041704786 cites W2003944081 @default.
- W2041704786 cites W2009793758 @default.
- W2041704786 cites W2060917067 @default.
- W2041704786 cites W2061848121 @default.
- W2041704786 cites W2097201441 @default.
- W2041704786 cites W2105668259 @default.
- W2041704786 cites W2155523753 @default.
- W2041704786 cites W37711660 @default.
- W2041704786 doi "https://doi.org/10.1021/jm0101747" @default.
- W2041704786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728189" @default.
- W2041704786 hasPublicationYear "2001" @default.
- W2041704786 type Work @default.
- W2041704786 sameAs 2041704786 @default.
- W2041704786 citedByCount "376" @default.
- W2041704786 countsByYear W20417047862012 @default.
- W2041704786 countsByYear W20417047862013 @default.
- W2041704786 countsByYear W20417047862014 @default.
- W2041704786 countsByYear W20417047862015 @default.
- W2041704786 countsByYear W20417047862016 @default.
- W2041704786 countsByYear W20417047862017 @default.
- W2041704786 countsByYear W20417047862018 @default.
- W2041704786 countsByYear W20417047862019 @default.
- W2041704786 countsByYear W20417047862020 @default.
- W2041704786 countsByYear W20417047862021 @default.
- W2041704786 countsByYear W20417047862022 @default.
- W2041704786 countsByYear W20417047862023 @default.
- W2041704786 crossrefType "journal-article" @default.
- W2041704786 hasAuthorship W2041704786A5008476416 @default.
- W2041704786 hasAuthorship W2041704786A5029259484 @default.
- W2041704786 hasAuthorship W2041704786A5038348164 @default.
- W2041704786 hasConcept C150903083 @default.
- W2041704786 hasConcept C155647269 @default.
- W2041704786 hasConcept C178790620 @default.
- W2041704786 hasConcept C181199279 @default.
- W2041704786 hasConcept C185592680 @default.
- W2041704786 hasConcept C202751555 @default.
- W2041704786 hasConcept C207001950 @default.
- W2041704786 hasConcept C2776309666 @default.
- W2041704786 hasConcept C2779485729 @default.
- W2041704786 hasConcept C2780378348 @default.
- W2041704786 hasConcept C2781116151 @default.
- W2041704786 hasConcept C55493867 @default.
- W2041704786 hasConcept C71240020 @default.
- W2041704786 hasConcept C86803240 @default.
- W2041704786 hasConceptScore W2041704786C150903083 @default.
- W2041704786 hasConceptScore W2041704786C155647269 @default.
- W2041704786 hasConceptScore W2041704786C178790620 @default.
- W2041704786 hasConceptScore W2041704786C181199279 @default.
- W2041704786 hasConceptScore W2041704786C185592680 @default.
- W2041704786 hasConceptScore W2041704786C202751555 @default.
- W2041704786 hasConceptScore W2041704786C207001950 @default.
- W2041704786 hasConceptScore W2041704786C2776309666 @default.
- W2041704786 hasConceptScore W2041704786C2779485729 @default.
- W2041704786 hasConceptScore W2041704786C2780378348 @default.
- W2041704786 hasConceptScore W2041704786C2781116151 @default.
- W2041704786 hasConceptScore W2041704786C55493867 @default.
- W2041704786 hasConceptScore W2041704786C71240020 @default.
- W2041704786 hasConceptScore W2041704786C86803240 @default.
- W2041704786 hasIssue "25" @default.
- W2041704786 hasLocation W20417047861 @default.
- W2041704786 hasLocation W20417047862 @default.
- W2041704786 hasOpenAccess W2041704786 @default.
- W2041704786 hasPrimaryLocation W20417047861 @default.
- W2041704786 hasRelatedWork W113026154 @default.
- W2041704786 hasRelatedWork W1966138009 @default.
- W2041704786 hasRelatedWork W1994325596 @default.
- W2041704786 hasRelatedWork W2066198338 @default.
- W2041704786 hasRelatedWork W2069734281 @default.
- W2041704786 hasRelatedWork W2074236139 @default.
- W2041704786 hasRelatedWork W2173718656 @default.
- W2041704786 hasRelatedWork W2349301072 @default.
- W2041704786 hasRelatedWork W2604155874 @default.
- W2041704786 hasRelatedWork W2755333115 @default.
- W2041704786 hasVolume "44" @default.
- W2041704786 isParatext "false" @default.
- W2041704786 isRetracted "false" @default.
- W2041704786 magId "2041704786" @default.
- W2041704786 workType "article" @default.