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- W2041707678 abstract "Propofol infusion syndrome is a recognized complication of prolonged propofol use in the pediatric population, but little is reported on other metabolic effects of propofol, especially in children with mitochondrial disorders. We report on a child with metabolic encephalopathy, lactic acidosis, and stroke-like syndrome who received a single dose of propofol for procedural sedation. The patient’s initial presentation was consistent with a mild exacerbation of her underlying disease. She received a single dose of propofol and non–dextrose-containing fluids during a magnetic resonance imaging (MRI) study to rule out stroke and progressed to develop severe acidosis, neurologic deterioration, and cardiorespiratory compromise. This is the first case report of severe metabolic disturbances after a single dose of propofol administered for procedural sedation in a patient with metabolic encephalopathy, lactic acidosis, and stroke-like syndrome and it questions the safety of propofol and absence of dextrose infusions during an acute illness in patients with mitochondrial disorders." @default.
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- W2041707678 date "2013-09-11" @default.
- W2041707678 modified "2023-10-16" @default.
- W2041707678 title "Effect of a Single Dose of Propofol and Lack of Dextrose Administration in a Child With Mitochondrial Disease" @default.
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- W2041707678 doi "https://doi.org/10.1177/0883073813498640" @default.
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