FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041710080> ?p ?o ?g. }

• W2041710080 endingPage "444" @default.
• W2041710080 startingPage "437" @default.
• W2041710080 abstract "The effect of a single administration of aromatic hydrocarbons (AHCs) on the metabolic activity responsible for the biotransformation of dichloromethane (DCM) to carbon monoxide (CO) was investigated using adult female rats. In rats treated orally with benzene (1.5 ml kg−1), toluene (2.0 ml kg−1) or m-xylene (2.0 ml kg−1) 16–24 h prior to DCM (3 mmol kg−1, i.p.), the carboxyhaemoglobin (COHb) level was elevated, reaching peaks in blood at 21%, 16% and 23%, respectively, compared to the peak of ca. 10% in rats treated with DCM only. Their effects on COHb generation were highly dependent on the time interval between each AHC and DCM treatment, since an early administration of m-xylene or toluene decreased the COHb elevation. The half-life of DCM in blood was shortened significantly, indicating that the metabolic degradation of DCM was enhanced by the AHCs. Disulfiram (3.4 mmol kg−1, p.o.) blocked COHb elevation completely, suggesting that the metabolic conversion of DCM to CO is mediated by cytochrome P-450 2E1 (P4502E1). Corresponding increases in the concentration and half-life of DCM in blood were also observed. A single administration of the AHCs did not alter the hepatic glutathione level, suggesting that the increase in DCM-induced COHb elevation was not due to hepatic glutathione depletion. In vitro studies showed that the hepatic microsomal metabolism of nitrosodimethylamine and p-nitrophenol was significantly increased by a single dose of each AHC. Total cytochrome P-450 content and p-nitroanisole demethylase activity were also increased; however, only toluene and m-xylene were effective inducers for aminopyrine N-demethylase. Therefore, benzene appears to be a selective inducer for P4502E1 compared to other alkylbenzenes. The results indicate that even a single dose of benzene, toluene or m-xylene may induce the activity of P4502E1 significantly, which is responsible for the increased generation of COHb from DCM, as demonstrated in the present study." @default.
• W2041710080 created "2016-06-24" @default.
• W2041710080 creator A5005998951 @default.
• W2041710080 creator A5048393355 @default.
• W2041710080 date "1996-09-01" @default.
• W2041710080 modified "2023-10-01" @default.
• W2041710080 title "Effect of a Single Administration of Benzene, Toluene orm-Xylene on Carboxyhaemoglobin Elevation and Metabolism of Dichloromethane in Rats" @default.
• W2041710080 cites W1548732703 @default.
• W2041710080 cites W1775749144 @default.
• W2041710080 cites W1806194750 @default.
• W2041710080 cites W1924535555 @default.
• W2041710080 cites W1990187530 @default.
• W2041710080 cites W1991716901 @default.
• W2041710080 cites W1999687129 @default.
• W2041710080 cites W2005981883 @default.
• W2041710080 cites W2017911623 @default.
• W2041710080 cites W2052165802 @default.
• W2041710080 cites W2065529720 @default.
• W2041710080 cites W2085187554 @default.
• W2041710080 cites W2086876789 @default.
• W2041710080 cites W2096728068 @default.
• W2041710080 cites W2105342603 @default.
• W2041710080 cites W2105868009 @default.
• W2041710080 cites W2166848521 @default.
• W2041710080 cites W2525738745 @default.
• W2041710080 doi "https://doi.org/10.1002/(sici)1099-1263(199609)16:5<437::aid-jat371>3.0.co;2-2" @default.
• W2041710080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8889796" @default.
• W2041710080 hasPublicationYear "1996" @default.
• W2041710080 type Work @default.
• W2041710080 sameAs 2041710080 @default.
• W2041710080 citedByCount "31" @default.
• W2041710080 countsByYear W20417100802012 @default.
• W2041710080 countsByYear W20417100802014 @default.
• W2041710080 countsByYear W20417100802018 @default.
• W2041710080 countsByYear W20417100802021 @default.
• W2041710080 countsByYear W20417100802022 @default.
• W2041710080 crossrefType "journal-article" @default.
• W2041710080 hasAuthorship W2041710080A5005998951 @default.
• W2041710080 hasAuthorship W2041710080A5048393355 @default.
• W2041710080 hasConcept C126322002 @default.
• W2041710080 hasConcept C134018914 @default.
• W2041710080 hasConcept C140027455 @default.
• W2041710080 hasConcept C161790260 @default.
• W2041710080 hasConcept C181199279 @default.
• W2041710080 hasConcept C185592680 @default.
• W2041710080 hasConcept C202751555 @default.
• W2041710080 hasConcept C2776378800 @default.
• W2041710080 hasConcept C2780400988 @default.
• W2041710080 hasConcept C2780471494 @default.
• W2041710080 hasConcept C2780768313 @default.
• W2041710080 hasConcept C43617362 @default.
• W2041710080 hasConcept C512735826 @default.
• W2041710080 hasConcept C526171541 @default.
• W2041710080 hasConcept C538909803 @default.
• W2041710080 hasConcept C55493867 @default.
• W2041710080 hasConcept C62231903 @default.
• W2041710080 hasConcept C71924100 @default.
• W2041710080 hasConcept C87644729 @default.
• W2041710080 hasConcept C98274493 @default.
• W2041710080 hasConceptScore W2041710080C126322002 @default.
• W2041710080 hasConceptScore W2041710080C134018914 @default.
• W2041710080 hasConceptScore W2041710080C140027455 @default.
• W2041710080 hasConceptScore W2041710080C161790260 @default.
• W2041710080 hasConceptScore W2041710080C181199279 @default.
• W2041710080 hasConceptScore W2041710080C185592680 @default.
• W2041710080 hasConceptScore W2041710080C202751555 @default.
• W2041710080 hasConceptScore W2041710080C2776378800 @default.
• W2041710080 hasConceptScore W2041710080C2780400988 @default.
• W2041710080 hasConceptScore W2041710080C2780471494 @default.
• W2041710080 hasConceptScore W2041710080C2780768313 @default.
• W2041710080 hasConceptScore W2041710080C43617362 @default.
• W2041710080 hasConceptScore W2041710080C512735826 @default.
• W2041710080 hasConceptScore W2041710080C526171541 @default.
• W2041710080 hasConceptScore W2041710080C538909803 @default.
• W2041710080 hasConceptScore W2041710080C55493867 @default.
• W2041710080 hasConceptScore W2041710080C62231903 @default.
• W2041710080 hasConceptScore W2041710080C71924100 @default.
• W2041710080 hasConceptScore W2041710080C87644729 @default.
• W2041710080 hasConceptScore W2041710080C98274493 @default.
• W2041710080 hasIssue "5" @default.
• W2041710080 hasLocation W20417100801 @default.
• W2041710080 hasLocation W20417100802 @default.
• W2041710080 hasOpenAccess W2041710080 @default.
• W2041710080 hasPrimaryLocation W20417100801 @default.
• W2041710080 hasRelatedWork W1971311720 @default.
• W2041710080 hasRelatedWork W2009107699 @default.
• W2041710080 hasRelatedWork W2018189884 @default.
• W2041710080 hasRelatedWork W2082986101 @default.
• W2041710080 hasRelatedWork W2086635406 @default.
• W2041710080 hasRelatedWork W2095562928 @default.
• W2041710080 hasRelatedWork W2158517500 @default.
• W2041710080 hasRelatedWork W2336838307 @default.
• W2041710080 hasRelatedWork W2408869886 @default.
• W2041710080 hasRelatedWork W2419414102 @default.
• W2041710080 hasVolume "16" @default.
• W2041710080 isParatext "false" @default.
• W2041710080 isRetracted "false" @default.
• W2041710080 magId "2041710080" @default.

• next