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- W2041710646 abstract "Abstract Injections of bretylium tosylate, a ganglion-blocking agent in newborn rats, result in selective degenerative changes of mitochondria of the immature sympathetic neurons. Although all nerve cells are affected, only some show irreversible degenerative changes such as cell membrane rupture and nuclear pyknosis. Under the electron microscope the mitochondria appear enormously enlarged in size and empty. Residual cristae float freely in the mitochondrial cavity. Discontinuation of the treatment is followed by a partial recovery. Sympathetic ganglia of one-month-old rats treated with bretylium tosylate for the first two weeks of life are smaller than controls, but the surviving nerve cells appear normal. Optical and electron microscopic studies of other organs and tissues from the same animals show no mitochondrial lesions or other degenerative changes. The alterations elicited by bretylium tosylate in sympathetic immature neurons are compared with those called forth by other ganglion-blocking agents, such as 6-hydroxydopamine, reserpine and guanethidine, in the same nerve cells. A different site and mechanism of action of bretylium tosylate and the pharmacological agents mentioned above are indicated by these findings." @default.
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- W2041710646 date "1972-05-01" @default.
- W2041710646 modified "2023-09-27" @default.
- W2041710646 title "Mitochondrial lesions of developing sympathetic neurons induced by bretylium tosylate" @default.
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- W2041710646 doi "https://doi.org/10.1016/0006-8993(72)90131-x" @default.
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