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• W2041712852 abstract "We tested the hypothesis that no threshold exists when estradiol acts through the same mechanism as an active endogenous estrogen. A Michaelis-Menten (MM) equation accounting for response saturation, background effects, and endogenous estrogen level fit a turtle sex-reversal data set with no threshold and estimated the endogenous dose. Additionally, 31 diverse literature dose-response data sets were analyzed by adding a term for nonhormonal background; good fits were obtained but endogenous dose estimations were not significant due to low resolving power. No thresholds were observed. Data sets were plotted using a normalized MM equation; all 178 data points were accommodated on a single graph. Response rates from approximately 1% to >95% were well fit. The findings contradict the threshold assumption and low-dose safety. Calculating risk and assuming additivity of effects from multiple chemicals acting through the same mechanism rather than assuming a safe dose for nonthresholded curves is appropriate." @default.
• W2041712852 created "2016-06-24" @default.
• W2041712852 creator A5057015055 @default.
• W2041712852 date "2006-01-01" @default.
• W2041712852 modified "2023-10-17" @default.
• W2041712852 title "No-threshold dose–response curves for nongenotoxic chemicals: Findings and applications for risk assessment" @default.
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• W2041712852 doi "https://doi.org/10.1016/j.envres.2005.09.002" @default.
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