FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041738474> ?p ?o ?g. }

• W2041738474 endingPage "68" @default.
• W2041738474 startingPage "56" @default.
• W2041738474 abstract "Background: Good compliance to the prescribed dosing regimen and inhaler instructions for use are critical for asthma/chronic obstructive pulmonary disease (COPD) patients to achieve good control of their disease. We investigated the extent to which a system comprising porous particles delivered with a passive dry powder inhaler could be designed to achieve significant reductions in dose inhalation errors. Methods: Porous placebo particles were prepared by an emulsion-based spray-drying method (PulmoSphere® technology). The formulations were administered as dry powders with a portable, blister-based dry powder inhaler (Simoon Inhaler). The inhalation profiles of 69 asthma/COPD subjects were determined with an inhaler simulator with resistance comparable to that of the Simoon Inhaler. Powder emptying from the device was assessed by laser photometry. Aerosol performance was assessed on a Next Generation Impactor, and with the idealized Alberta mouth-throat model using both square-wave and subject-inhalation profiles generated in the breathing study. Results: Virtually all subjects could achieve a pressure drop of at least 1 kPa and an inhaled volume of at least 500 mL with the Simoon Inhaler. In vitro measures of particle deposition were found to be largely independent of the inhalation maneuver (flow rate, inhaled volume, ramp time) across the broad range of inhalation profiles observed in the breathing study. The rapid emptying of powder from the Simoon Inhaler minimizes the impact of dose-related errors, such as failure to exhale before inhalation and failure to breath-hold post inhalation. Conclusions: Inertial impaction that is largely independent of a subject's inhalation maneuver can be achieved with a drug/device combination product comprising a porous particle formulation and blister-based inhaler." @default.
• W2041738474 created "2016-06-24" @default.
• W2041738474 creator A5012707989 @default.
• W2041738474 creator A5013658600 @default.
• W2041738474 creator A5031849937 @default.
• W2041738474 creator A5032220382 @default.
• W2041738474 creator A5063668833 @default.
• W2041738474 creator A5065531971 @default.
• W2041738474 creator A5072088354 @default.
• W2041738474 creator A5084219294 @default.
• W2041738474 date "2013-02-01" @default.
• W2041738474 modified "2023-10-17" @default.
• W2041738474 title "Dose Emission Characteristics of Placebo PulmoSphere^®Particles Are Unaffected by a Subject's Inhalation Maneuver" @default.
• W2041738474 cites W1504654291 @default.
• W2041738474 cites W1607515676 @default.
• W2041738474 cites W1935602610 @default.
• W2041738474 cites W1970397305 @default.
• W2041738474 cites W1973043185 @default.
• W2041738474 cites W1974860230 @default.
• W2041738474 cites W1993898178 @default.
• W2041738474 cites W1999386525 @default.
• W2041738474 cites W2002594100 @default.
• W2041738474 cites W2008624656 @default.
• W2041738474 cites W2009198143 @default.
• W2041738474 cites W2016127775 @default.
• W2041738474 cites W2021023200 @default.
• W2041738474 cites W2025303383 @default.
• W2041738474 cites W2026766056 @default.
• W2041738474 cites W2031533780 @default.
• W2041738474 cites W2033872754 @default.
• W2041738474 cites W2034362616 @default.
• W2041738474 cites W2035911015 @default.
• W2041738474 cites W2041472021 @default.
• W2041738474 cites W2041601011 @default.
• W2041738474 cites W2043599529 @default.
• W2041738474 cites W2050730934 @default.
• W2041738474 cites W2058889783 @default.
• W2041738474 cites W2068797397 @default.
• W2041738474 cites W2074053180 @default.
• W2041738474 cites W2092626137 @default.
• W2041738474 cites W2096872979 @default.
• W2041738474 cites W2102356444 @default.
• W2041738474 cites W2116478659 @default.
• W2041738474 cites W2117983629 @default.
• W2041738474 cites W2120444716 @default.
• W2041738474 cites W2120799202 @default.
• W2041738474 cites W2144298091 @default.
• W2041738474 cites W2148923589 @default.
• W2041738474 cites W2151367154 @default.
• W2041738474 cites W2158509702 @default.
• W2041738474 cites W2172031255 @default.
• W2041738474 cites W2174826642 @default.
• W2041738474 cites W2230519420 @default.
• W2041738474 cites W4242164352 @default.
• W2041738474 doi "https://doi.org/10.1089/jamp.2012.0973" @default.
• W2041738474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22691109" @default.
• W2041738474 hasPublicationYear "2013" @default.
• W2041738474 type Work @default.
• W2041738474 sameAs 2041738474 @default.
• W2041738474 citedByCount "29" @default.
• W2041738474 countsByYear W20417384742014 @default.
• W2041738474 countsByYear W20417384742015 @default.
• W2041738474 countsByYear W20417384742016 @default.
• W2041738474 countsByYear W20417384742019 @default.
• W2041738474 countsByYear W20417384742020 @default.
• W2041738474 countsByYear W20417384742021 @default.
• W2041738474 countsByYear W20417384742022 @default.
• W2041738474 crossrefType "journal-article" @default.
• W2041738474 hasAuthorship W2041738474A5012707989 @default.
• W2041738474 hasAuthorship W2041738474A5013658600 @default.
• W2041738474 hasAuthorship W2041738474A5031849937 @default.
• W2041738474 hasAuthorship W2041738474A5032220382 @default.
• W2041738474 hasAuthorship W2041738474A5063668833 @default.
• W2041738474 hasAuthorship W2041738474A5065531971 @default.
• W2041738474 hasAuthorship W2041738474A5072088354 @default.
• W2041738474 hasAuthorship W2041738474A5084219294 @default.
• W2041738474 hasConcept C126322002 @default.
• W2041738474 hasConcept C2776042228 @default.
• W2041738474 hasConcept C2776780178 @default.
• W2041738474 hasConcept C2776954882 @default.
• W2041738474 hasConcept C2777419714 @default.
• W2041738474 hasConcept C2780261241 @default.
• W2041738474 hasConcept C2780667556 @default.
• W2041738474 hasConcept C42219234 @default.
• W2041738474 hasConcept C71924100 @default.
• W2041738474 hasConceptScore W2041738474C126322002 @default.
• W2041738474 hasConceptScore W2041738474C2776042228 @default.
• W2041738474 hasConceptScore W2041738474C2776780178 @default.
• W2041738474 hasConceptScore W2041738474C2776954882 @default.
• W2041738474 hasConceptScore W2041738474C2777419714 @default.
• W2041738474 hasConceptScore W2041738474C2780261241 @default.
• W2041738474 hasConceptScore W2041738474C2780667556 @default.
• W2041738474 hasConceptScore W2041738474C42219234 @default.
• W2041738474 hasConceptScore W2041738474C71924100 @default.
• W2041738474 hasIssue "1" @default.
• W2041738474 hasLocation W20417384741 @default.
• W2041738474 hasLocation W20417384742 @default.
• W2041738474 hasOpenAccess W2041738474 @default.

• next