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- W2041741036 abstract "The flash evoked ERG is used extensively as a measure of retinal function. To understand better the relationship between extent of retinal damage and the ERG we created multistage laser lesions in one eye each of three Macaca fascicularis monkeys. An argon-dye laser was used to deliver 630 nm energy to cumulative quarter sectors of the temporal hemiretina and the foveal region at two week intervals. Latencies of the a- and b-waves and amplitude from the trough of the a-wave to peak of the b-wave were measured preoperatively and one week after each new lesion. Following the last recording session the eyes were removed and prepared for histological examination. In general, but depending on stimulus condition, the maximum decrease in ERG amplitude (50–70% of normal) occurred following the third or fourth sector lesions. These lesions accounted for a loss of the outer nuclear layer in 18–25% of the entire retinal surface area extending from the edge of the fovea into the anterior equatorial region. Surprisingly, subsequent lesions of the remaining sector and fovea did not result in further reduction of ERG amplitudes.Significant increases in amplitudes were even observed for some stimulus conditions following these final lesions. Latencies of the a- and b-waves were not affected. The fact that in the present study ERG amplitudes recovered, suggest that such values may be tenuous evidence of amount of functional retina in laser-lesioned eyes." @default.
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- W2041741036 date "1990-01-01" @default.
- W2041741036 modified "2023-09-23" @default.
- W2041741036 title "Changes in ERG amplitude following laser induced damage to the primate retina" @default.
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- W2041741036 doi "https://doi.org/10.3109/02713689008999609" @default.
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