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- W2041755480 endingPage "701" @default.
- W2041755480 startingPage "677" @default.
- W2041755480 abstract "Approximately half of children with acute myeloid leukemia (AML) can be cured with contemporary chemotherapy regimens; however, various forms of drug resistance pose considerable obstacles for curing the remaining patients. Recent advances in immunology, cytogenetics, and cellular and molecular biology have provided new insights into fundamental biological differences between leukemic myeloid blasts and their normal counterparts. This article focuses on new technologies involving: (1) antibody- or growth factor-mediated targeting of antigens or growth factor receptors found on AML blasts and restricted sub-groups of normal cells, (2) pharmacologic targeting of the pathologic t(15;17) translocation of acute promyelocytic leukemia with all-trans retinoic acid, (3) pharmacologic and immunologic targeting of mutant RAS oncogenes and related aberrant signaling in AML blasts, and (4) targeting of pathological signaling of the Bcr-Abl oncoprotein and c-kit tyrosine kinase in myeloid leukemias. These advances herald an exciting new era of AML-specific therapies." @default.
- W2041755480 created "2016-06-24" @default.
- W2041755480 creator A5031662456 @default.
- W2041755480 creator A5076408794 @default.
- W2041755480 date "2001-08-01" @default.
- W2041755480 modified "2023-10-16" @default.
- W2041755480 title "Targeted Therapies for High-Risk Acute Myeloid Leukemia" @default.
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