Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041769222> ?p ?o ?g. }
- W2041769222 endingPage "552" @default.
- W2041769222 startingPage "543" @default.
- W2041769222 abstract "DNA variants in the tumor necrosis factor-α (TNF) and linked lymphotoxin-α genes, and specific alleles of the highly polymorphic human leukocyte antigen B (HLA-B) gene have been implicated in a plethora of immune and infectious diseases. However, the tight linkage disequilibrium characterizing the central region of the human major histocompatibility complex (MHC) containing these gene loci has made difficult the unequivocal interpretation of genetic association data. To alleviate these difficulties and facilitate the design of more focused follow-up studies, we investigated the structure and distribution of HLA-B-specific MHC haplotypes reconstructed in a European population from unphased genotypes at a set of 25 single nucleotide polymorphism sites spanning a 66-kilobase long region across TNF. Consistent with the published data, we found limited genetic diversity across the so-called TNF block, with the emergence of seven common MHC haplotypes, termed TNF block super-haplotypes. We also found that the ancestral haplotype 8.1 shares a TNF block haplotype with HLA-B*4402. HLA-B*5701, a known protective allele in HIV-1 pathogenesis, occurred in a unique TNF block haplotype." @default.
- W2041769222 created "2016-06-24" @default.
- W2041769222 creator A5021151605 @default.
- W2041769222 creator A5071063677 @default.
- W2041769222 creator A5072740925 @default.
- W2041769222 creator A5075524664 @default.
- W2041769222 date "2013-04-12" @default.
- W2041769222 modified "2023-09-25" @default.
- W2041769222 title "Structure of tumor necrosis factor-alpha haploblocks in European populations" @default.
- W2041769222 cites W1965999876 @default.
- W2041769222 cites W1968475820 @default.
- W2041769222 cites W1970599818 @default.
- W2041769222 cites W1973288013 @default.
- W2041769222 cites W1979713976 @default.
- W2041769222 cites W1980189971 @default.
- W2041769222 cites W2003025881 @default.
- W2041769222 cites W2003370133 @default.
- W2041769222 cites W2005062591 @default.
- W2041769222 cites W2008408573 @default.
- W2041769222 cites W2016370312 @default.
- W2041769222 cites W2022771327 @default.
- W2041769222 cites W2024218493 @default.
- W2041769222 cites W2026054511 @default.
- W2041769222 cites W2030678748 @default.
- W2041769222 cites W2038697192 @default.
- W2041769222 cites W2043394305 @default.
- W2041769222 cites W2044720356 @default.
- W2041769222 cites W2046185375 @default.
- W2041769222 cites W2061542205 @default.
- W2041769222 cites W2062540811 @default.
- W2041769222 cites W2062774841 @default.
- W2041769222 cites W2063999310 @default.
- W2041769222 cites W2067688068 @default.
- W2041769222 cites W2073739597 @default.
- W2041769222 cites W2081197388 @default.
- W2041769222 cites W2082361552 @default.
- W2041769222 cites W2088204382 @default.
- W2041769222 cites W2091319016 @default.
- W2041769222 cites W2093245824 @default.
- W2041769222 cites W2093437136 @default.
- W2041769222 cites W2097421327 @default.
- W2041769222 cites W2099671460 @default.
- W2041769222 cites W2104756573 @default.
- W2041769222 cites W2107414939 @default.
- W2041769222 cites W2115428390 @default.
- W2041769222 cites W2116150697 @default.
- W2041769222 cites W2119083333 @default.
- W2041769222 cites W2122455852 @default.
- W2041769222 cites W2123584222 @default.
- W2041769222 cites W2127768738 @default.
- W2041769222 cites W2131184245 @default.
- W2041769222 cites W2132499964 @default.
- W2041769222 cites W2135969743 @default.
- W2041769222 cites W2136170659 @default.
- W2041769222 cites W2137631018 @default.
- W2041769222 cites W2140841968 @default.
- W2041769222 cites W2141380939 @default.
- W2041769222 cites W2144413932 @default.
- W2041769222 cites W2145378546 @default.
- W2041769222 cites W2152381343 @default.
- W2041769222 cites W2153778605 @default.
- W2041769222 cites W2154936664 @default.
- W2041769222 cites W2156090925 @default.
- W2041769222 cites W2156175813 @default.
- W2041769222 cites W2169157594 @default.
- W2041769222 cites W2169985285 @default.
- W2041769222 cites W2170093170 @default.
- W2041769222 cites W2170821252 @default.
- W2041769222 doi "https://doi.org/10.1007/s00251-013-0700-2" @default.
- W2041769222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985396" @default.
- W2041769222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23579626" @default.
- W2041769222 hasPublicationYear "2013" @default.
- W2041769222 type Work @default.
- W2041769222 sameAs 2041769222 @default.
- W2041769222 citedByCount "9" @default.
- W2041769222 countsByYear W20417692222014 @default.
- W2041769222 countsByYear W20417692222016 @default.
- W2041769222 countsByYear W20417692222018 @default.
- W2041769222 countsByYear W20417692222019 @default.
- W2041769222 countsByYear W20417692222020 @default.
- W2041769222 countsByYear W20417692222021 @default.
- W2041769222 crossrefType "journal-article" @default.
- W2041769222 hasAuthorship W2041769222A5021151605 @default.
- W2041769222 hasAuthorship W2041769222A5071063677 @default.
- W2041769222 hasAuthorship W2041769222A5072740925 @default.
- W2041769222 hasAuthorship W2041769222A5075524664 @default.
- W2041769222 hasBestOaLocation W20417692222 @default.
- W2041769222 hasConcept C104317684 @default.
- W2041769222 hasConcept C135763542 @default.
- W2041769222 hasConcept C147483822 @default.
- W2041769222 hasConcept C153209595 @default.
- W2041769222 hasConcept C180754005 @default.
- W2041769222 hasConcept C188280979 @default.
- W2041769222 hasConcept C197754878 @default.
- W2041769222 hasConcept C207936829 @default.
- W2041769222 hasConcept C35605836 @default.
- W2041769222 hasConcept C44432683 @default.
- W2041769222 hasConcept C54355233 @default.