Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041774032> ?p ?o ?g. }
- W2041774032 endingPage "574" @default.
- W2041774032 startingPage "563" @default.
- W2041774032 abstract "Although studies in 2D cell culture systems have provided great insights into the biology and pathogenesis of HIV-1 infection, such studies cannot account for many aspects of host physiology that affect HIV-1in vivo. Fackler et al. discuss the development and application of more integrative studies, including organotypic 3D culture systems, small-animal models and advanced live-cell imaging, and the impact of such studies on our understanding of the mechanisms of HIV-1 spread. In vitro studies in primary or immortalized cells continue to be used to elucidate the essential principles that govern the interactions between HIV-1 and isolated target cells. However, until recently, substantial technical barriers prevented this information from being efficiently translated to the more complex scenario of HIV-1 spread in the host in vivo, which has limited our understanding of the impact of host physiological parameters on the spread of HIV-1. In this Review, we discuss the recent development of imaging approaches to visualize HIV-1 spread and the adaptation of these approaches to organotypic ex vivo models and animal models. We focus on new concepts, including the mechanisms and in vivo relevance of cell–cell transmission for HIV-1 spread and the function of the HIV-1 pathogenesis factor Nef, which have emerged from the application of these integrative approaches in complex cell systems." @default.
- W2041774032 created "2016-06-24" @default.
- W2041774032 creator A5011493742 @default.
- W2041774032 creator A5045409518 @default.
- W2041774032 creator A5046531312 @default.
- W2041774032 creator A5061635112 @default.
- W2041774032 date "2014-07-16" @default.
- W2041774032 modified "2023-10-09" @default.
- W2041774032 title "Adding new dimensions: towards an integrative understanding of HIV-1 spread" @default.
- W2041774032 cites W1033069450 @default.
- W2041774032 cites W1543952889 @default.
- W2041774032 cites W1674854702 @default.
- W2041774032 cites W1948272231 @default.
- W2041774032 cites W1964093787 @default.
- W2041774032 cites W1966635724 @default.
- W2041774032 cites W1967690324 @default.
- W2041774032 cites W1968201178 @default.
- W2041774032 cites W1968640383 @default.
- W2041774032 cites W1969003615 @default.
- W2041774032 cites W1974096769 @default.
- W2041774032 cites W1978574683 @default.
- W2041774032 cites W1984238344 @default.
- W2041774032 cites W1984595045 @default.
- W2041774032 cites W1984645508 @default.
- W2041774032 cites W1988759080 @default.
- W2041774032 cites W1990836784 @default.
- W2041774032 cites W1995249775 @default.
- W2041774032 cites W1996400917 @default.
- W2041774032 cites W1996684522 @default.
- W2041774032 cites W1997434968 @default.
- W2041774032 cites W2002574877 @default.
- W2041774032 cites W2007428391 @default.
- W2041774032 cites W2007922771 @default.
- W2041774032 cites W2009898112 @default.
- W2041774032 cites W2012490203 @default.
- W2041774032 cites W2013703920 @default.
- W2041774032 cites W2013886463 @default.
- W2041774032 cites W2015727594 @default.
- W2041774032 cites W2015776459 @default.
- W2041774032 cites W2016118097 @default.
- W2041774032 cites W2016967864 @default.
- W2041774032 cites W2018002636 @default.
- W2041774032 cites W2018312298 @default.
- W2041774032 cites W2018534819 @default.
- W2041774032 cites W2019070114 @default.
- W2041774032 cites W2019206924 @default.
- W2041774032 cites W2020827708 @default.
- W2041774032 cites W2022280258 @default.
- W2041774032 cites W2023650184 @default.
- W2041774032 cites W2025346994 @default.
- W2041774032 cites W2026927504 @default.
- W2041774032 cites W2029379203 @default.
- W2041774032 cites W2029930485 @default.
- W2041774032 cites W2030541908 @default.
- W2041774032 cites W2033087883 @default.
- W2041774032 cites W2035538295 @default.
- W2041774032 cites W2036129024 @default.
- W2041774032 cites W2039062327 @default.
- W2041774032 cites W2039484612 @default.
- W2041774032 cites W2039767921 @default.
- W2041774032 cites W2040015246 @default.
- W2041774032 cites W2040066829 @default.
- W2041774032 cites W2044555293 @default.
- W2041774032 cites W2045645323 @default.
- W2041774032 cites W2046714652 @default.
- W2041774032 cites W2049069843 @default.
- W2041774032 cites W2050737543 @default.
- W2041774032 cites W2051695714 @default.
- W2041774032 cites W2051931389 @default.
- W2041774032 cites W2054395379 @default.
- W2041774032 cites W2055047552 @default.
- W2041774032 cites W2057271096 @default.
- W2041774032 cites W2057567758 @default.
- W2041774032 cites W2060139150 @default.
- W2041774032 cites W2061464631 @default.
- W2041774032 cites W2063465748 @default.
- W2041774032 cites W2063825303 @default.
- W2041774032 cites W2064557078 @default.
- W2041774032 cites W2065794926 @default.
- W2041774032 cites W2066406164 @default.
- W2041774032 cites W2068111695 @default.
- W2041774032 cites W2070063923 @default.
- W2041774032 cites W2070278092 @default.
- W2041774032 cites W2073273867 @default.
- W2041774032 cites W2074458816 @default.
- W2041774032 cites W2075785440 @default.
- W2041774032 cites W2077039119 @default.
- W2041774032 cites W2078078834 @default.
- W2041774032 cites W2080415772 @default.
- W2041774032 cites W2080674820 @default.
- W2041774032 cites W2082354489 @default.
- W2041774032 cites W2083044021 @default.
- W2041774032 cites W2083283696 @default.
- W2041774032 cites W2086960330 @default.
- W2041774032 cites W2088632182 @default.
- W2041774032 cites W2088757776 @default.
- W2041774032 cites W2090611257 @default.
- W2041774032 cites W2091174536 @default.