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• W2041784037 abstract "Objective We aimed to investigate the role of caveolin-1 in papillary thyroid carcinoma pathogenesis. Study Design Case series with chart review. Setting Institute for the Application of Nuclear Energy. Subjects and Methods We evaluated the expression of caveolin-1 in papillary thyroid carcinoma (PTC) by Western blot (WB) and compared the findings with immunohistochemical (IHC) expression of both epithelial and stromal caveolin-1 on the corresponding histological specimens. The results were related to clinicopathological features and BRAF mutation status. Results Caveolin-1 expression was found in malignant thyroid epithelium and more abundantly in tumor stroma but varied in both compartments within and between PTC subtypes. Caveolin-1 expression in the epithelium was more intense in classical PTC than in the other histological types. On the contrary, stromal caveolin-1 expression was stronger in the follicular, solid, and trabecular PTC variants than in classical PTC. Trends for down-regulation of caveolin-1 expression in epithelium and up-regulation in stroma from the classical via follicular to the solid variant were observed. The relation of WB and IHC results with clinicopathological parameters showed lower caveolin-1 tissue content in BRAF mutated tumors ( P < .05), a positive correlation of epithelial caveolin-1 expression with lymph node metastasis ( P < .05), and a negative association of stromal caveolin-1 expression with the degree of neoplastic infiltration and BRAF status. Conclusion Altered expression of caveolin-1 in the thyroid epithelial and stromal compartments may be involved in the pathogenesis of PTC. The potential clinical significance of caveolin-1 expression, as well as its relation to BRAF mutation status, deserves further investigation." @default.
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• W2041784037 date "2013-11-19" @default.
• W2041784037 modified "2023-10-17" @default.
• W2041784037 title "Caveolin-1 Expression in Papillary Thyroid Carcinoma" @default.
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• W2041784037 doi "https://doi.org/10.1177/0194599813512781" @default.
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