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• W2041796674 abstract "Abstract Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor‐ κ B ligand (RANKL). The aim of this study was to correlate T‐helper type 1 (Th1), Th2, Th17 and Treg transcription factor expressions, in gingival tissues from patients undergoing active periodontal tissue destruction, with bone loss‐associated cytokines. Materials and Methods: In 10 chronic periodontitis patients undergoing disease progression, the mRNA expressions of T‐bet, GATA‐3, Foxp3, RORC2, interleukin (IL)‐1 β , IL‐10, IL‐17, RANKL, interferon (IFN)‐ γ and transforming growth factor (TGF)‐ β 1 were quantified using real‐time reverse transcription‐polymerase chain reaction. The levels of these markers were compared between active and inactive periodontal lesions. Results: In active periodontal lesions, Foxp3, T‐bet, RANKL, IL‐17, IL‐1 β and IFN‐ γ were significantly over‐expressed compared with inactive lesions. The expression of IFN‐ γ was the highest within the active periodontal lesions, similar to that of TGF‐ β 1 within the inactive ones. There was a positive correlation between RANKL and IL‐17. Additionally, RANKL and IL‐17 were positively correlated with RORC2, but no correlation was detected with Foxp3. Conclusions: These results lead us to speculate that Foxp3 + cells that do not have a regulatory function might have a role in the pathogenesis of active periodontal lesions by down‐regulating TGF‐ β 1 and IL‐10 synthesis that lead to the over‐expression of Th17‐associated cytokines RANKL and IL‐17." @default.
• W2041796674 created "2016-06-24" @default.
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• W2041796674 date "2009-04-15" @default.
• W2041796674 modified "2023-10-12" @default.
• W2041796674 title "Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-<i>κ</i>B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-<i>β</i>during the progression of chronic periodontitis" @default.
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• W2041796674 doi "https://doi.org/10.1111/j.1600-051x.2009.01390.x" @default.
• W2041796674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19419438" @default.
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