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• W2041803434 abstract "The hematopoietic cytokines erythropoietin (Epo) and granulocyte-colony stimulating factor (G-CSF) provide neuroprotection in several in vitro and in vivo models of Parkinson's disease (PD). The molecular mechanism by which Epo and G-CSF signals reduce the neuronal death in PD is not clear. Here, we show that in rat pheochromocytoma PC12 cells, Epo and G-CSF efficiently repressed the 1-methyl-4-phenylpyridinium (MPP(+))-induced expression of the proapoptotic protein PUMA (p53 up-regulated modulator of apoptosis). Accordingly, Epo and G-CSF treatment reduced the PC12 cell fraction that underwent apoptosis by MPP(+) treatment and thus improved cell viability. Downregulation of PUMA expression by Epo and G-CSF in MPP(+)-treated PC12 cells seems to be mediated by repression of p53, as the expression of p53 was increased by MPP(+)-treatment and reduced by Epo and G-CSF. Together, these results suggest that the neuroprotective activities of Epo and G-CSF in an experimental model of PD involve the repression of the apoptosis-inducing action of PUMA." @default.
• W2041803434 created "2016-06-24" @default.
• W2041803434 creator A5057851218 @default.
• W2041803434 creator A5068551830 @default.
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• W2041803434 date "2011-07-01" @default.
• W2041803434 modified "2023-09-24" @default.
• W2041803434 title "Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP+) model of Parkinson’s disease" @default.
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• W2041803434 doi "https://doi.org/10.1016/j.bbrc.2011.06.151" @default.
• W2041803434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21741364" @default.
• W2041803434 hasPublicationYear "2011" @default.
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