Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041805028> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2041805028 endingPage "392" @default.
- W2041805028 startingPage "387" @default.
- W2041805028 abstract "The malaria parasite, Plasmodium falciparum, unlike its human host, utilizes type II fatty acid synthesis, in which steps of fatty acid biosynthesis are catalyzed by independent enzymes. Due to this difference, the enzymes of this pathway are a potential target of newer antimalarials. Here we report the functional characterization of Plasmodium FabG expressed in Escherichia coli. The purified recombinant FabG from P. falciparum is soluble and active. The K(m) of the enzyme for acetoacetyl-CoA was estimated to be 75 microM with a V(max) of 0.0054 micromol/min/ml and a k(cat) value of 0.014s(-1). NADPH exhibited negative cooperativity for its interaction with FabG. We have also modeled P. falciparum FabG using Brassica napus FabG as the template. This model provides a structural rationale for the specificity of FabG towards its cofactor, NADPH." @default.
- W2041805028 created "2016-06-24" @default.
- W2041805028 creator A5025823748 @default.
- W2041805028 creator A5058922118 @default.
- W2041805028 creator A5068879729 @default.
- W2041805028 creator A5075388956 @default.
- W2041805028 creator A5079274884 @default.
- W2041805028 creator A5086698158 @default.
- W2041805028 date "2003-03-01" @default.
- W2041805028 modified "2023-09-24" @default.
- W2041805028 title "Functional characterization of β-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum" @default.
- W2041805028 cites W1499640952 @default.
- W2041805028 cites W1608320698 @default.
- W2041805028 cites W1980027504 @default.
- W2041805028 cites W1989656015 @default.
- W2041805028 cites W2004901557 @default.
- W2041805028 cites W2049679577 @default.
- W2041805028 cites W2050136339 @default.
- W2041805028 cites W2052151676 @default.
- W2041805028 cites W2065524541 @default.
- W2041805028 cites W2072982982 @default.
- W2041805028 cites W2076297587 @default.
- W2041805028 cites W2076532708 @default.
- W2041805028 cites W2093331306 @default.
- W2041805028 cites W2097981550 @default.
- W2041805028 cites W2098749606 @default.
- W2041805028 cites W2106882534 @default.
- W2041805028 cites W2123616487 @default.
- W2041805028 cites W2133917166 @default.
- W2041805028 cites W2139765199 @default.
- W2041805028 cites W2145783899 @default.
- W2041805028 cites W27632074 @default.
- W2041805028 doi "https://doi.org/10.1016/s0006-291x(03)00321-8" @default.
- W2041805028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12646215" @default.
- W2041805028 hasPublicationYear "2003" @default.
- W2041805028 type Work @default.
- W2041805028 sameAs 2041805028 @default.
- W2041805028 citedByCount "40" @default.
- W2041805028 countsByYear W20418050282012 @default.
- W2041805028 countsByYear W20418050282013 @default.
- W2041805028 countsByYear W20418050282014 @default.
- W2041805028 countsByYear W20418050282015 @default.
- W2041805028 countsByYear W20418050282017 @default.
- W2041805028 countsByYear W20418050282018 @default.
- W2041805028 countsByYear W20418050282019 @default.
- W2041805028 countsByYear W20418050282021 @default.
- W2041805028 countsByYear W20418050282023 @default.
- W2041805028 crossrefType "journal-article" @default.
- W2041805028 hasAuthorship W2041805028A5025823748 @default.
- W2041805028 hasAuthorship W2041805028A5058922118 @default.
- W2041805028 hasAuthorship W2041805028A5068879729 @default.
- W2041805028 hasAuthorship W2041805028A5075388956 @default.
- W2041805028 hasAuthorship W2041805028A5079274884 @default.
- W2041805028 hasAuthorship W2041805028A5086698158 @default.
- W2041805028 hasConcept C166014724 @default.
- W2041805028 hasConcept C181199279 @default.
- W2041805028 hasConcept C185592680 @default.
- W2041805028 hasConcept C203014093 @default.
- W2041805028 hasConcept C2778048844 @default.
- W2041805028 hasConcept C2778371730 @default.
- W2041805028 hasConcept C55493867 @default.
- W2041805028 hasConcept C86803240 @default.
- W2041805028 hasConceptScore W2041805028C166014724 @default.
- W2041805028 hasConceptScore W2041805028C181199279 @default.
- W2041805028 hasConceptScore W2041805028C185592680 @default.
- W2041805028 hasConceptScore W2041805028C203014093 @default.
- W2041805028 hasConceptScore W2041805028C2778048844 @default.
- W2041805028 hasConceptScore W2041805028C2778371730 @default.
- W2041805028 hasConceptScore W2041805028C55493867 @default.
- W2041805028 hasConceptScore W2041805028C86803240 @default.
- W2041805028 hasIssue "1" @default.
- W2041805028 hasLocation W20418050281 @default.
- W2041805028 hasLocation W20418050282 @default.
- W2041805028 hasOpenAccess W2041805028 @default.
- W2041805028 hasPrimaryLocation W20418050281 @default.
- W2041805028 hasRelatedWork W1850986032 @default.
- W2041805028 hasRelatedWork W1995488937 @default.
- W2041805028 hasRelatedWork W1998637266 @default.
- W2041805028 hasRelatedWork W2041559206 @default.
- W2041805028 hasRelatedWork W2065019097 @default.
- W2041805028 hasRelatedWork W2088063203 @default.
- W2041805028 hasRelatedWork W2126061209 @default.
- W2041805028 hasRelatedWork W2411187914 @default.
- W2041805028 hasRelatedWork W2768045943 @default.
- W2041805028 hasRelatedWork W4242974861 @default.
- W2041805028 hasVolume "303" @default.
- W2041805028 isParatext "false" @default.
- W2041805028 isRetracted "false" @default.
- W2041805028 magId "2041805028" @default.
- W2041805028 workType "article" @default.