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- W2041808526 abstract "Flow through the vasculature of an experimental rat glioma has been investigated during in situ perfusion of the brain, via the ascending aorta, with a simple saline solution. Using such a system, it has been shown previously that the blood-brain barrier will remain intact with an adequate cerebral perfusate flow rate for at least 10 min, providing that the metabolic inhibitor 2,4-dinitrophenol is present. Cerebral perfusate flow rate was measured in both tumour and non-tumour areas using [14C] iodoantipyrine. The perfusion pump rate was set between 4.8 and 84 ml/min in different animals and the mean flow rate for cerebral hemisphere remote from the tumour was 1.03 +/- 0.67 ml/min/g (mean +/- sd; n = 17) whereas that for intracerebral tumour was considerably lower at 0.060 +/- 0.11 ml/min/g (mean +/- sd; n = 17). Linear regression of tumour flow on cerebrum flow showed a highly significant correlation (r = 0.88). Light and electron microscope examination of the tumour vessels revealed no luminal obstruction or perivascular oedema to explain the low flow. We suggest that perfusion with a low viscosity medium, at flow rates that result in a low intraluminal pressure, probably causes glioma vessels to close preferentially because they require a higher intraluminal pressure to remain patent than do normal cerebral vessels." @default.
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- W2041808526 date "1994-10-01" @default.
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- W2041808526 title "Selective closure of the vascular bed of an experimental glioma model during in situ saline perfusion" @default.
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- W2041808526 doi "https://doi.org/10.1111/j.1365-2990.1994.tb00995.x" @default.
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