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- W2041853008 abstract "Abstract Changes in the levels of oxidative enzyme activities and hemoproteins in chicken liver microsomes were studied during late embryonic and post-hatching development and following administration of phenobarbital at several developmental stages. 1. 1. During the developmental period studied, the oxidative N-demethylation and NADPH-cytochrome c reductase activities increased markedly and in parallel fashion, while oxidative O-demethylation and cytochrome b5 increased only slightly and at a different developmental stage, and the cytochrome P-450 level did not increase. Phenobarbital treatment caused marked increases in the cytochrome P-450 level and N-demethylation activity at each developmental stage, but only minor changes in cytochrome b5 level, O-demethylation activity or capacity for electron transport from NADH or NADPH to cytochrome c or to oxygen. 2. 2. Spectroscopic studies with microsome suspensions indicate that the avian liver microsomal cytochrome P-450 is similar to the mammalian hemoprotein in its spectral properties and lability. 3. 3. The characteristics of the avian microsomal mixed-function oxidase system are considered in the light of the developmental and induced changes in the levels of oxidative components." @default.
- W2041853008 created "2016-06-24" @default.
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- W2041853008 date "1969-05-01" @default.
- W2041853008 modified "2023-09-24" @default.
- W2041853008 title "Oxidative enzyme components of avian liver microsomes. Changes during embryonic development and the effects of phenobarbital administration" @default.
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- W2041853008 doi "https://doi.org/10.1016/0005-2728(69)90189-3" @default.
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