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• W2041859413 abstract "Introduction: The objective of this study was to determine whether the circulatory levels of endothelins, potent vasoconstrictor polypeptides produced mainly by endothelial cells, are increased in growth-retarded fetuses. Study design: Fetal venous serum samples, withdrawn by ultrasound-guided cordocentesis from 11 growth-retarded fetuses and 10 normally-growing fetuses who underwent the procedure because of other unrelated indications, were examined for immunoreactive endothelin-1,2 by radioimmunoassay. Results: Higher mean endothelin-1,2 levels were found in the sera of growth-retarded fetuses than in controls (16.8 ± 4.2 versus 10.9 ± 4.3 fmol/ml, p = 0.008). Within the growth-retarded group, there were no differences in endothelin-1,2 levels in the presence of either abnormal umbilical Doppler, asymmetry of growth-retardation, maternal signs of preeclampsia, or fetal acidosis. Conclusion: High levels of endothelin-1,2 in the fetoplacental circulation may be pathophysiological important in fetal growth retardation. However, the clinical significance of these elevated levels is yet to be determined." @default.
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• W2041859413 date "1994-01-01" @default.
• W2041859413 modified "2023-10-07" @default.
• W2041859413 title "Endothelin-1,2 levels in umbilical vein serum of intra-uterine growth retarded fetuses as detected by cordocentesis" @default.
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• W2041859413 doi "https://doi.org/10.3109/00016349409013387" @default.
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