FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041878139> ?p ?o ?g. }

• W2041878139 endingPage "59" @default.
• W2041878139 startingPage "51" @default.
• W2041878139 abstract "To determine the stability of bimatoprost, latanoprost, and travoprost under conditions of simulated daily use and varying degrees of thermal stress.Commercially available bimatoprost, latanoprost, and travoprost were obtained in their original bottles as distributed by the manufacturers. Bottles were stored in calibrated, nonhumidified, light-free incubators maintained at 27°C, 37°C, or 50°C for 3, 9, 15, or 30 days. Capped bottles were inverted and left uncapped for 1 min daily to simulate patient use; no drops were expelled. Bimatoprost concentration was analyzed using liquid chromatography with ultraviolet detection at 210 nm. Latanoprost and travoprost concentrations were analyzed by liquid chromatography/tandem mass spectrometry (MS/MS) using selected reaction monitoring.Off-the-shelf control bottles of bimatoprost contained 102% of the labeled concentration. In all combinations of stress temperature and duration, mean bimatoprost concentration ranged from 100% to 116% of the labeled concentration with no measurable degradation. Off-the-shelf control bottles of latanoprost contained 115% of the labeled concentration. Mean latanoprost concentration ranged from 97% to 120% of the labeled concentration. Latanoprost was stable at 27°C. When stressed at 37°C or 50°C, latanoprost degraded at a rate of 0.15 or 0.29 μg/mL/day, respectively. Off-the-shelf control bottles of travoprost contained 120% of the labeled concentration. Mean travoprost concentration ranged from 83% to 142% of the labeled concentration. Travoprost was stable at 27°C and 37°C, although concentration measurements at 37°C exhibited high variability. When stressed at 50°C, travoprost degraded at a rate of 0.46 μg/mL/day.Higher than expected concentrations for stressed drug samples are likely a result of evaporation. Under the conditions of thermal stress tested in this study, bimatoprost remained stable for all conditions tested. Latanoprost degradation was measurable only in samples stressed at 37°C and 50°C, whereas travoprost degradation was statistically significant only in samples stressed at 50°C." @default.
• W2041878139 created "2016-06-24" @default.
• W2041878139 creator A5004821778 @default.
• W2041878139 creator A5006003679 @default.
• W2041878139 creator A5027677816 @default.
• W2041878139 creator A5072082254 @default.
• W2041878139 creator A5079384190 @default.
• W2041878139 date "2011-02-01" @default.
• W2041878139 modified "2023-09-26" @default.
• W2041878139 title "Thermal Stability of Bimatoprost, Latanoprost, and Travoprost Under Simulated Daily Use" @default.
• W2041878139 cites W1987574116 @default.
• W2041878139 cites W2000248632 @default.
• W2041878139 cites W2001191546 @default.
• W2041878139 cites W2006726419 @default.
• W2041878139 cites W2006971510 @default.
• W2041878139 cites W2010983269 @default.
• W2041878139 cites W2012012658 @default.
• W2041878139 cites W2027565439 @default.
• W2041878139 cites W2033076859 @default.
• W2041878139 cites W2034011121 @default.
• W2041878139 cites W2043769051 @default.
• W2041878139 cites W2047770662 @default.
• W2041878139 cites W2057266151 @default.
• W2041878139 cites W2080974592 @default.
• W2041878139 cites W2089508678 @default.
• W2041878139 cites W2099523789 @default.
• W2041878139 cites W2101994642 @default.
• W2041878139 cites W2110897487 @default.
• W2041878139 cites W2122691108 @default.
• W2041878139 cites W2130771173 @default.
• W2041878139 cites W2132045077 @default.
• W2041878139 cites W2136654293 @default.
• W2041878139 cites W2140290681 @default.
• W2041878139 cites W2140594570 @default.
• W2041878139 cites W2144103368 @default.
• W2041878139 cites W2148890166 @default.
• W2041878139 cites W2325154459 @default.
• W2041878139 cites W2625521663 @default.
• W2041878139 cites W2913596175 @default.
• W2041878139 cites W2977587116 @default.
• W2041878139 doi "https://doi.org/10.1089/jop.2010.0115" @default.
• W2041878139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3038126" @default.
• W2041878139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21117945" @default.
• W2041878139 hasPublicationYear "2011" @default.
• W2041878139 type Work @default.
• W2041878139 sameAs 2041878139 @default.
• W2041878139 citedByCount "23" @default.
• W2041878139 countsByYear W20418781392013 @default.
• W2041878139 countsByYear W20418781392014 @default.
• W2041878139 countsByYear W20418781392015 @default.
• W2041878139 countsByYear W20418781392016 @default.
• W2041878139 countsByYear W20418781392017 @default.
• W2041878139 countsByYear W20418781392018 @default.
• W2041878139 countsByYear W20418781392019 @default.
• W2041878139 countsByYear W20418781392020 @default.
• W2041878139 countsByYear W20418781392022 @default.
• W2041878139 countsByYear W20418781392023 @default.
• W2041878139 crossrefType "journal-article" @default.
• W2041878139 hasAuthorship W2041878139A5004821778 @default.
• W2041878139 hasAuthorship W2041878139A5006003679 @default.
• W2041878139 hasAuthorship W2041878139A5027677816 @default.
• W2041878139 hasAuthorship W2041878139A5072082254 @default.
• W2041878139 hasAuthorship W2041878139A5079384190 @default.
• W2041878139 hasBestOaLocation W20418781392 @default.
• W2041878139 hasConcept C118487528 @default.
• W2041878139 hasConcept C179998833 @default.
• W2041878139 hasConcept C185592680 @default.
• W2041878139 hasConcept C2776740260 @default.
• W2041878139 hasConcept C2777336333 @default.
• W2041878139 hasConcept C2778527774 @default.
• W2041878139 hasConcept C2780276452 @default.
• W2041878139 hasConcept C43617362 @default.
• W2041878139 hasConcept C71924100 @default.
• W2041878139 hasConceptScore W2041878139C118487528 @default.
• W2041878139 hasConceptScore W2041878139C179998833 @default.
• W2041878139 hasConceptScore W2041878139C185592680 @default.
• W2041878139 hasConceptScore W2041878139C2776740260 @default.
• W2041878139 hasConceptScore W2041878139C2777336333 @default.
• W2041878139 hasConceptScore W2041878139C2778527774 @default.
• W2041878139 hasConceptScore W2041878139C2780276452 @default.
• W2041878139 hasConceptScore W2041878139C43617362 @default.
• W2041878139 hasConceptScore W2041878139C71924100 @default.
• W2041878139 hasIssue "1" @default.
• W2041878139 hasLocation W20418781391 @default.
• W2041878139 hasLocation W20418781392 @default.
• W2041878139 hasLocation W20418781393 @default.
• W2041878139 hasLocation W20418781394 @default.
• W2041878139 hasOpenAccess W2041878139 @default.
• W2041878139 hasPrimaryLocation W20418781391 @default.
• W2041878139 hasRelatedWork W164455875 @default.
• W2041878139 hasRelatedWork W1966103856 @default.
• W2041878139 hasRelatedWork W2007653567 @default.
• W2041878139 hasRelatedWork W2098532635 @default.
• W2041878139 hasRelatedWork W2128476364 @default.
• W2041878139 hasRelatedWork W2187702626 @default.
• W2041878139 hasRelatedWork W2346781353 @default.
• W2041878139 hasRelatedWork W2398343149 @default.
• W2041878139 hasRelatedWork W4205865038 @default.

• next