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• W2041889948 abstract "The mineralocorticoid receptor (MR), a member of the steroid receptor family, regulates blood pressure by mediating the effects of the hormone aldosterone (Aldo) on renal sodium handling. Over the past decade, it has become clear that MR is expressed in the cardiovascular system and interest has grown in understanding the direct role of the MR in regulating vascular function and contributing to cardiovascular disease. This interest stems from multiple clinical studies in which drugs that decrease MR activation also reduce the incidence of heart attacks, strokes, and mortality out of proportion to modest changes in systemic blood pressure. The presence of functional mineralocorticoid receptors in vascular smooth muscle and endothelial cells is now well established and, while still controversial, data supports the vasculature as an Aldo-responsive tissue. This review summarizes recent advances in our understanding of the role of vascular MR in regulating normal vascular function and in promoting vascular disease. In vitro data, in vivo animal studies, and human data are reviewed suggesting a role for MR-activation in promoting vascular oxidative stress, inhibiting vascular relaxation, and contributing to vessel inflammation, fibrosis, and remodeling. These detrimental vascular effects of MR activation appear to be independent of changes in blood pressure and are synergistic with the presence of endothelial dysfunction or damage. Thus, in humans with underlying cardiovascular disease or cardiovascular risk factors, vascular MR activation may promote vascular aging and atherosclerosis thereby contributing to the pathophysiology of heart attack, stroke, and possibly even hypertension. Further exploration of the molecular mechanisms for the detrimental vascular effects of MR activation has the potential to identify novel therapeutic targets to prevent or treat common cardiovascular disorders." @default.
• W2041889948 created "2016-06-24" @default.
• W2041889948 creator A5015102832 @default.
• W2041889948 creator A5019926661 @default.
• W2041889948 date "2012-03-01" @default.
• W2041889948 modified "2023-10-17" @default.
• W2041889948 title "Mineralocorticoid receptors in vascular function and disease" @default.
• W2041889948 cites W1518760783 @default.
• W2041889948 cites W1558440797 @default.
• W2041889948 cites W1963232607 @default.
• W2041889948 cites W1965301500 @default.
• W2041889948 cites W1965883240 @default.
• W2041889948 cites W1967567897 @default.
• W2041889948 cites W1967783942 @default.
• W2041889948 cites W1969734795 @default.
• W2041889948 cites W1969889097 @default.
• W2041889948 cites W1972003997 @default.
• W2041889948 cites W1972977873 @default.
• W2041889948 cites W1973355122 @default.
• W2041889948 cites W1978736086 @default.
• W2041889948 cites W1980629926 @default.
• W2041889948 cites W1982177470 @default.
• W2041889948 cites W1983323298 @default.
• W2041889948 cites W1984057831 @default.
• W2041889948 cites W1985050616 @default.
• W2041889948 cites W1987827916 @default.
• W2041889948 cites W1990001636 @default.
• W2041889948 cites W1993014176 @default.
• W2041889948 cites W1993016877 @default.
• W2041889948 cites W1994041118 @default.
• W2041889948 cites W1995829325 @default.
• W2041889948 cites W1998793050 @default.
• W2041889948 cites W2005000807 @default.
• W2041889948 cites W2008269136 @default.
• W2041889948 cites W2010743737 @default.
• W2041889948 cites W2011515563 @default.
• W2041889948 cites W2012714305 @default.
• W2041889948 cites W2012840031 @default.
• W2041889948 cites W2013495761 @default.
• W2041889948 cites W2015497140 @default.
• W2041889948 cites W2016132786 @default.
• W2041889948 cites W2017884988 @default.
• W2041889948 cites W2018299587 @default.
• W2041889948 cites W2018928665 @default.
• W2041889948 cites W2024398257 @default.
• W2041889948 cites W2026474627 @default.
• W2041889948 cites W2028186012 @default.
• W2041889948 cites W2031486533 @default.
• W2041889948 cites W2032144770 @default.
• W2041889948 cites W2033995962 @default.
• W2041889948 cites W2034832260 @default.
• W2041889948 cites W2034914625 @default.
• W2041889948 cites W2035367937 @default.
• W2041889948 cites W2040671157 @default.
• W2041889948 cites W2044561526 @default.
• W2041889948 cites W2048760408 @default.
• W2041889948 cites W2055033932 @default.
• W2041889948 cites W2065875003 @default.
• W2041889948 cites W2074149689 @default.
• W2041889948 cites W2075383085 @default.
• W2041889948 cites W2076206901 @default.
• W2041889948 cites W2076541362 @default.
• W2041889948 cites W2080422687 @default.
• W2041889948 cites W2081508823 @default.
• W2041889948 cites W2081513299 @default.
• W2041889948 cites W2082752407 @default.
• W2041889948 cites W2086392932 @default.
• W2041889948 cites W2087342173 @default.
• W2041889948 cites W2087957273 @default.
• W2041889948 cites W2089717835 @default.
• W2041889948 cites W2090227784 @default.
• W2041889948 cites W2096111588 @default.
• W2041889948 cites W2097552698 @default.
• W2041889948 cites W2101551652 @default.
• W2041889948 cites W2106624199 @default.
• W2041889948 cites W2107418117 @default.
• W2041889948 cites W2109560663 @default.
• W2041889948 cites W2110362194 @default.
• W2041889948 cites W2111001345 @default.
• W2041889948 cites W2114557242 @default.
• W2041889948 cites W2115255784 @default.
• W2041889948 cites W2116087989 @default.
• W2041889948 cites W2116392383 @default.
• W2041889948 cites W2119084971 @default.
• W2041889948 cites W2119264856 @default.
• W2041889948 cites W2120763912 @default.
• W2041889948 cites W2124317932 @default.
• W2041889948 cites W2126820850 @default.
• W2041889948 cites W2128236156 @default.
• W2041889948 cites W2131715702 @default.
• W2041889948 cites W2131885909 @default.
• W2041889948 cites W2133217116 @default.
• W2041889948 cites W2135519224 @default.
• W2041889948 cites W2136714451 @default.
• W2041889948 cites W2137032419 @default.
• W2041889948 cites W2138366753 @default.
• W2041889948 cites W2139167395 @default.
• W2041889948 cites W2139764595 @default.

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