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- W2041896075 abstract "4-Methoxy-2-(phenylthio)benzoic acid ( V ) was transformed in four steps to the homologous acid IXa which was cyclized to 3-methoxydibenzo[ b,f ]thiepin-10(11 H )-one ( Xa ). The 3-methoxy derivative III of perathiepin ( I ) was synthesized via the intermediates XIa and XIIa , and demethylated with boron tribromide to the phenolic compound II . The analogous 3-fluoro derivative IV was synthesized from (4-fluoro-2-iodophenyl)acetic acid ( XVII ), the preparation of which by several procedures is described. Whereas III has only mild tranquilizing activity, II is more potent than perathiepin ( I ) in the tests for central depressant and cataleptic effects. The 3-fluoro derivative IV , while lacking the properties of a neuroleptic agent, is highly central depressant and this effect shows some prolongation after oral administration." @default.
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- W2041896075 date "1979-01-01" @default.
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- W2041896075 title "Potential metabolites of tricyclic neuroleptics and their fluorinated analogues; 3-Hydroxy-, 3-methoxy- and 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin" @default.
- W2041896075 doi "https://doi.org/10.1135/cccc19792108" @default.
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