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• W2041921444 abstract "Prostaglandin E2 (PGE2) regulates production of a wide array of cytokines. We have found that PGE2 can upregulate the levels of both interleukin-10 (IL-10) and IL-6 produced by activated murine macrophages, but the molecular pathways leading to their augmentation differ. Synthesis of IL-10 in response to PGE2 is dependent on p38 MAP kinase activity, whereas synthesis of IL-6 is not. Evidence to support this derives from two experimental approaches. First, we established that PGE2 is effective in elevating IL-10 levels only when it is added to cells in which p38 kinase has been activated. In contrast, PGE2 can augment IL-6 levels regardless of whether or not p38 kinase is active. Second, we showed that inhibitors that are selective for p38 kinase prevent the IL-10 response to PGE2 but not the IL-6 response. We found that p38 kinase inhibitors are able to inhibit IL-6 production in activated macrophages, but this occurs primarily as a result of their concurrent inhibition of cyclooxygenase-2 and endogenous PGE2 synthesis. These results indicate that macrophage IL-10 and IL-6 expression is differentially regulated by PGE2 and p38 MAP kinase in murine inflammatory macrophages." @default.
• W2041921444 created "2016-06-24" @default.
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• W2041921444 creator A5058555394 @default.
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• W2041921444 date "2000-03-01" @default.
• W2041921444 modified "2023-09-26" @default.
• W2041921444 title "Regulation of Macrophage Interleukin-6 (IL-6) and IL-10 Expression by Prostaglandin E₂: The Role of p38 Mitogen-Activated Protein Kinase" @default.
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• W2041921444 doi "https://doi.org/10.1089/107999000312423" @default.
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