Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041937331> ?p ?o ?g. }
- W2041937331 endingPage "e29054" @default.
- W2041937331 startingPage "e29054" @default.
- W2041937331 abstract "Prostaglandin F(2α) (PGF(2α)) induces luteolysis within a few days in cows, and immune cells increase in number in the regressing corpus luteum (CL), implying that luteolysis is an inflammatory-like immune response. We investigated the rapid change in polymorphonuclear neutrophil (PMN) numbers in response to PGF(2α) administration as the first cells recruited to inflammatory sites, together with mRNA of interleukin-8 (IL-8: neutrophil chemoattractant) and P-selectin (leukocyte adhesion molecule) in the bovine CL. CLs were collected by ovariectomy at various times after PGF(2α) injection. The number of PMNs was increased at 5 min after PGF(2α) administration, whereas IL-8 and P-selectin mRNA increased at 30 min and 2 h, respectively. PGF(2α) directly stimulated P-selectin protein expression at 5-30 min in luteal endothelial cells (LECs). Moreover, PGF(2α) enhanced PMN adhesion to LECs, and this enhancement by PGF(2α) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2α) is crucial in PMN migration. In conclusion, PGF(2α) rapidly induces the accumulation of PMNs into the bovine CL at 5 min and enhances PMN adhesion via P-selectin expression in LECs. It is suggested that luteolytic cascade by PGF(2α) may involve an acute inflammatory-like response due to rapidly infiltrated PMNs." @default.
- W2041937331 created "2016-06-24" @default.
- W2041937331 creator A5016429154 @default.
- W2041937331 creator A5017855796 @default.
- W2041937331 creator A5020012457 @default.
- W2041937331 creator A5050021829 @default.
- W2041937331 creator A5054994098 @default.
- W2041937331 creator A5059138509 @default.
- W2041937331 creator A5061027903 @default.
- W2041937331 creator A5089045231 @default.
- W2041937331 date "2012-01-03" @default.
- W2041937331 modified "2023-10-14" @default.
- W2041937331 title "Rapid Accumulation of Polymorphonuclear Neutrophils in the Corpus luteum during Prostaglandin F2α-Induced Luteolysis in the Cow" @default.
- W2041937331 cites W1491969685 @default.
- W2041937331 cites W1969608322 @default.
- W2041937331 cites W1970354692 @default.
- W2041937331 cites W1973277351 @default.
- W2041937331 cites W1974853601 @default.
- W2041937331 cites W1975694155 @default.
- W2041937331 cites W1980186261 @default.
- W2041937331 cites W1980770348 @default.
- W2041937331 cites W1986851731 @default.
- W2041937331 cites W1989596343 @default.
- W2041937331 cites W1999958927 @default.
- W2041937331 cites W2000706956 @default.
- W2041937331 cites W2006385139 @default.
- W2041937331 cites W2007831444 @default.
- W2041937331 cites W2012269283 @default.
- W2041937331 cites W2022636087 @default.
- W2041937331 cites W2023095547 @default.
- W2041937331 cites W2032992203 @default.
- W2041937331 cites W2041289994 @default.
- W2041937331 cites W2045406037 @default.
- W2041937331 cites W2047916715 @default.
- W2041937331 cites W2055912425 @default.
- W2041937331 cites W2057769061 @default.
- W2041937331 cites W2058401583 @default.
- W2041937331 cites W2066769255 @default.
- W2041937331 cites W2085119204 @default.
- W2041937331 cites W2086581168 @default.
- W2041937331 cites W2088343796 @default.
- W2041937331 cites W2088587450 @default.
- W2041937331 cites W2090593805 @default.
- W2041937331 cites W2104514705 @default.
- W2041937331 cites W2107994102 @default.
- W2041937331 cites W2121612992 @default.
- W2041937331 cites W2123388755 @default.
- W2041937331 cites W2127842687 @default.
- W2041937331 cites W2140957914 @default.
- W2041937331 cites W2158915807 @default.
- W2041937331 cites W2161395809 @default.
- W2041937331 cites W2164028133 @default.
- W2041937331 cites W2164190174 @default.
- W2041937331 cites W2416103104 @default.
- W2041937331 cites W4230693812 @default.
- W2041937331 cites W4294216491 @default.
- W2041937331 doi "https://doi.org/10.1371/journal.pone.0029054" @default.
- W2041937331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250407" @default.
- W2041937331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22235260" @default.
- W2041937331 hasPublicationYear "2012" @default.
- W2041937331 type Work @default.
- W2041937331 sameAs 2041937331 @default.
- W2041937331 citedByCount "36" @default.
- W2041937331 countsByYear W20419373312012 @default.
- W2041937331 countsByYear W20419373312013 @default.
- W2041937331 countsByYear W20419373312014 @default.
- W2041937331 countsByYear W20419373312015 @default.
- W2041937331 countsByYear W20419373312016 @default.
- W2041937331 countsByYear W20419373312017 @default.
- W2041937331 countsByYear W20419373312018 @default.
- W2041937331 countsByYear W20419373312019 @default.
- W2041937331 countsByYear W20419373312020 @default.
- W2041937331 countsByYear W20419373312021 @default.
- W2041937331 countsByYear W20419373312022 @default.
- W2041937331 crossrefType "journal-article" @default.
- W2041937331 hasAuthorship W2041937331A5016429154 @default.
- W2041937331 hasAuthorship W2041937331A5017855796 @default.
- W2041937331 hasAuthorship W2041937331A5020012457 @default.
- W2041937331 hasAuthorship W2041937331A5050021829 @default.
- W2041937331 hasAuthorship W2041937331A5054994098 @default.
- W2041937331 hasAuthorship W2041937331A5059138509 @default.
- W2041937331 hasAuthorship W2041937331A5061027903 @default.
- W2041937331 hasAuthorship W2041937331A5089045231 @default.
- W2041937331 hasBestOaLocation W20419373311 @default.
- W2041937331 hasConcept C126322002 @default.
- W2041937331 hasConcept C134018914 @default.
- W2041937331 hasConcept C143228043 @default.
- W2041937331 hasConcept C16685009 @default.
- W2041937331 hasConcept C185592680 @default.
- W2041937331 hasConcept C187785154 @default.
- W2041937331 hasConcept C203014093 @default.
- W2041937331 hasConcept C2776608385 @default.
- W2041937331 hasConcept C2777198256 @default.
- W2041937331 hasConcept C2777330693 @default.
- W2041937331 hasConcept C2778324911 @default.
- W2041937331 hasConcept C2780664492 @default.
- W2041937331 hasConcept C71924100 @default.
- W2041937331 hasConcept C86803240 @default.