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• W2041938678 abstract "Abstract The most important theories on aging are presented and the morphological and neurochemical aspects of the processes of aging in the brain are discussed. Considerably more evidence for specific changes with age can be found on the neurochemical than on the morphological side. The reduction in the capacity of the brain to adapt to metabolic stress situations is a manifestation of the progressive decrease, with advancing age, in the enzyme activity of aerobic energy metabolism. A special section is devoted to the difficulties involved in experimental studies with older laboratory animals, the limited number of species which are suitable for such work (rat, mouse, hamster) and the problems of building up colonies of these older animals. In the last part the significance of the progressive age dependent reduction in the functional tolerance range of oxygen consumption is discussed. Decreased metabolic capacity is part of the reduced adaptability to increased metabolic activity which is characteristic of the aging process. The extensive experimental pathological work carried out on the pathophysiology of ischemia and hypoxia within the framework of experimental brain research has today led to the use of such hypoxia models as screening methods being a prerequisite for the testing of geriatric pharmaceutical preparations in experimental pharmacology." @default.
• W2041938678 created "2016-06-24" @default.
• W2041938678 creator A5088585291 @default.
• W2041938678 date "1975-12-01" @default.
• W2041938678 modified "2023-09-25" @default.
• W2041938678 title "Experimental pathology and pharmacology in brain research and aging" @default.
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• W2041938678 doi "https://doi.org/10.1016/0024-3205(75)90107-1" @default.
• W2041938678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1107734" @default.
• W2041938678 hasPublicationYear "1975" @default.
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