FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041939076> ?p ?o ?g. }

• W2041939076 endingPage "e66130" @default.
• W2041939076 startingPage "e66130" @default.
• W2041939076 abstract "Despite recent pharmaceutical advancements in therapeutic drugs, multiple myeloma (MM) remains an incurable disease. Recently, ploy(ADP-ribose) polymerase 1 (PARP1) has been shown as a potentially promising target for MM therapy. A previous report suggested bufalin, a component of traditional Chinese medicine (“Chan Su”), might target PARP1. However, this hypothesis has not been verified. We here showed that bufalin could inhibit PARP1 activity in vitro and reduce DNA–damage-induced poly(ADP-ribosyl)ation in MM cells. Molecular docking analysis revealed that the active site of bufalin interaction is within the catalytic domain of PAPR1. Thus, PARP1 is a putative target of bufalin. Furthermore, we showed, for the first time that the proliferation of MM cell lines (NCI-H929, U266, RPMI8226 and MM.1S) and primary CD138+ MM cells could be inhibited by bufalin, mainly via apoptosis and G2-M phase cell cycle arrest. MM cell apoptosis was confirmed by apoptotic cell morphology, Annexin-V positive cells, and the caspase3 activation. We further evaluated the role of PARP1 in bufalin-induced apoptosis, discovering that PARP1 overexpression partially suppressed bufalin-induced cell death. Moreover, bufalin can act as chemosensitizer to enhance the cell growth-inhibitory effects of topotecan, camptothecin, etoposide and vorinostat in MM cells. Collectively, our data suggest that bufalin is a novel PARP1 inhibitor and a potentially promising therapeutic agent against MM alone or in combination with other drugs." @default.
• W2041939076 created "2016-06-24" @default.
• W2041939076 creator A5003642180 @default.
• W2041939076 creator A5003799076 @default.
• W2041939076 creator A5014323068 @default.
• W2041939076 creator A5034750589 @default.
• W2041939076 creator A5049338114 @default.
• W2041939076 creator A5052740395 @default.
• W2041939076 creator A5071037763 @default.
• W2041939076 creator A5080150992 @default.
• W2041939076 creator A5091381371 @default.
• W2041939076 date "2013-06-07" @default.
• W2041939076 modified "2023-10-17" @default.
• W2041939076 title "Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells" @default.
• W2041939076 cites W1599469009 @default.
• W2041939076 cites W1871475547 @default.
• W2041939076 cites W1965782508 @default.
• W2041939076 cites W1974209624 @default.
• W2041939076 cites W1974590528 @default.
• W2041939076 cites W1977348505 @default.
• W2041939076 cites W1980460135 @default.
• W2041939076 cites W1981510143 @default.
• W2041939076 cites W1981945171 @default.
• W2041939076 cites W1982819726 @default.
• W2041939076 cites W1984629445 @default.
• W2041939076 cites W1990946891 @default.
• W2041939076 cites W1992397774 @default.
• W2041939076 cites W1999010280 @default.
• W2041939076 cites W2009007206 @default.
• W2041939076 cites W2014283734 @default.
• W2041939076 cites W2015809424 @default.
• W2041939076 cites W2017981926 @default.
• W2041939076 cites W2018527946 @default.
• W2041939076 cites W2034401615 @default.
• W2041939076 cites W2040172810 @default.
• W2041939076 cites W2040255124 @default.
• W2041939076 cites W2048719138 @default.
• W2041939076 cites W2052183335 @default.
• W2041939076 cites W2052671064 @default.
• W2041939076 cites W2056920544 @default.
• W2041939076 cites W2056986047 @default.
• W2041939076 cites W2072603691 @default.
• W2041939076 cites W2075459072 @default.
• W2041939076 cites W2078483305 @default.
• W2041939076 cites W2089224502 @default.
• W2041939076 cites W2100462151 @default.
• W2041939076 cites W2101690394 @default.
• W2041939076 cites W2104093590 @default.
• W2041939076 cites W2149886520 @default.
• W2041939076 cites W2156883962 @default.
• W2041939076 cites W2161681893 @default.
• W2041939076 cites W2171972386 @default.
• W2041939076 cites W2184224810 @default.
• W2041939076 doi "https://doi.org/10.1371/journal.pone.0066130" @default.
• W2041939076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3676346" @default.
• W2041939076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23762475" @default.
• W2041939076 hasPublicationYear "2013" @default.
• W2041939076 type Work @default.
• W2041939076 sameAs 2041939076 @default.
• W2041939076 citedByCount "15" @default.
• W2041939076 countsByYear W20419390762014 @default.
• W2041939076 countsByYear W20419390762015 @default.
• W2041939076 countsByYear W20419390762016 @default.
• W2041939076 countsByYear W20419390762017 @default.
• W2041939076 countsByYear W20419390762018 @default.
• W2041939076 countsByYear W20419390762019 @default.
• W2041939076 countsByYear W20419390762022 @default.
• W2041939076 countsByYear W20419390762023 @default.
• W2041939076 crossrefType "journal-article" @default.
• W2041939076 hasAuthorship W2041939076A5003642180 @default.
• W2041939076 hasAuthorship W2041939076A5003799076 @default.
• W2041939076 hasAuthorship W2041939076A5014323068 @default.
• W2041939076 hasAuthorship W2041939076A5034750589 @default.
• W2041939076 hasAuthorship W2041939076A5049338114 @default.
• W2041939076 hasAuthorship W2041939076A5052740395 @default.
• W2041939076 hasAuthorship W2041939076A5071037763 @default.
• W2041939076 hasAuthorship W2041939076A5080150992 @default.
• W2041939076 hasAuthorship W2041939076A5091381371 @default.
• W2041939076 hasBestOaLocation W20419390761 @default.
• W2041939076 hasConcept C105696609 @default.
• W2041939076 hasConcept C182979987 @default.
• W2041939076 hasConcept C185592680 @default.
• W2041939076 hasConcept C190283241 @default.
• W2041939076 hasConcept C203014093 @default.
• W2041939076 hasConcept C2776364478 @default.
• W2041939076 hasConcept C2777151579 @default.
• W2041939076 hasConcept C2777478702 @default.
• W2041939076 hasConcept C2778480876 @default.
• W2041939076 hasConcept C29537977 @default.
• W2041939076 hasConcept C31573885 @default.
• W2041939076 hasConcept C502942594 @default.
• W2041939076 hasConcept C552990157 @default.
• W2041939076 hasConcept C55493867 @default.
• W2041939076 hasConcept C62112901 @default.
• W2041939076 hasConcept C82381507 @default.
• W2041939076 hasConcept C86803240 @default.
• W2041939076 hasConcept C98274493 @default.
• W2041939076 hasConceptScore W2041939076C105696609 @default.

• next