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• W2041945154 abstract "The salmon louse, Lepeophtheirus salmonis, is an ectoparasite of salmonids that causes huge economic losses in salmon farming, and has also been causatively linked with declines of wild salmonid populations. Lice control on farms is reliant upon a few groups of pesticides that have all shown time-limited efficiency due to resistance development. However, to date, this example of human-induced evolution is poorly documented at the population level due to the lack of molecular tools. As such, important evolutionary and management questions, linked to the development and dispersal of pesticide resistance in this parasite, remain unanswered. Here, we introduce the first Single Nucleotide Polymorphism (SNP) array for the salmon louse, which includes 6000 markers, and present a population genomic scan using this array on 576 lice from twelve farms distributed across the North Atlantic. Our results support the hypothesis of a single panmictic population of lice in the Atlantic, and importantly, revealed very strong selective sweeps on linkage groups 1 and 5. These sweeps included candidate genes potentially connected to pesticide resistance. After genotyping a further 576 lice from 12 full sibling families, a genome-wide association analysis established a highly significant association between the major sweep on linkage group 5 and resistance to emamectin benzoate, the most widely used pesticide in salmonid aquaculture for more than a decade. The analysis of conserved haplotypes across samples from the Atlantic strongly suggests that emamectin benzoate resistance developed at a single source, and rapidly spread across the Atlantic within the period 1999 when the chemical was first introduced, to 2010 when samples for the present study were obtained. These results provide unique insights into the development and spread of pesticide resistance in the marine environment, and identify a small genomic region strongly linked to emamectin benzoate resistance. Finally, these results have highly significant implications for the way pesticide resistance is considered and managed within the aquaculture industry." @default.
• W2041945154 created "2016-06-24" @default.
• W2041945154 creator A5052201211 @default.
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• W2041945154 creator A5085842865 @default.
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• W2041945154 date "2014-10-26" @default.
• W2041945154 modified "2023-10-06" @default.
• W2041945154 title "Human-induced evolution caught in action: SNP-array reveals rapid amphi-atlantic spread of pesticide resistance in the salmon ecotoparasite Lepeophtheirus salmonis" @default.
• W2041945154 cites W1039915491 @default.
• W2041945154 cites W1532903423 @default.
• W2041945154 cites W1546325539 @default.
• W2041945154 cites W1862968261 @default.
• W2041945154 cites W1932538605 @default.
• W2041945154 cites W1976049709 @default.
• W2041945154 cites W1979477032 @default.
• W2041945154 cites W1980477299 @default.
• W2041945154 cites W1980971846 @default.
• W2041945154 cites W1989685892 @default.
• W2041945154 cites W1990074132 @default.
• W2041945154 cites W2002591036 @default.
• W2041945154 cites W2006712471 @default.
• W2041945154 cites W2006999008 @default.
• W2041945154 cites W2008699938 @default.
• W2041945154 cites W2011842719 @default.
• W2041945154 cites W2012714287 @default.
• W2041945154 cites W2017548405 @default.
• W2041945154 cites W2017776406 @default.
• W2041945154 cites W2020383453 @default.
• W2041945154 cites W2021113636 @default.
• W2041945154 cites W2021810789 @default.
• W2041945154 cites W2024241931 @default.
• W2041945154 cites W2027617795 @default.
• W2041945154 cites W2027695993 @default.
• W2041945154 cites W2031460659 @default.
• W2041945154 cites W2035839217 @default.
• W2041945154 cites W2036187255 @default.
• W2041945154 cites W2038528464 @default.
• W2041945154 cites W2051994080 @default.
• W2041945154 cites W2052411676 @default.
• W2041945154 cites W2052698726 @default.
• W2041945154 cites W2054339231 @default.
• W2041945154 cites W2055043387 @default.
• W2041945154 cites W2057884822 @default.
• W2041945154 cites W2059051061 @default.
• W2041945154 cites W2059251678 @default.
• W2041945154 cites W2063395881 @default.
• W2041945154 cites W2067969435 @default.
• W2041945154 cites W2068183435 @default.
• W2041945154 cites W2071710914 @default.
• W2041945154 cites W2071921137 @default.
• W2041945154 cites W2072850446 @default.
• W2041945154 cites W2083878136 @default.
• W2041945154 cites W2084368341 @default.
• W2041945154 cites W2087470231 @default.
• W2041945154 cites W2089811859 @default.
• W2041945154 cites W2094198395 @default.
• W2041945154 cites W2098126593 @default.
• W2041945154 cites W2098460741 @default.
• W2041945154 cites W2098937968 @default.
• W2041945154 cites W2102851297 @default.
• W2041945154 cites W2102951980 @default.
• W2041945154 cites W2103441770 @default.
• W2041945154 cites W2105167794 @default.
• W2041945154 cites W2106397195 @default.
• W2041945154 cites W2106683328 @default.
• W2041945154 cites W2107934935 @default.
• W2041945154 cites W2108234281 @default.
• W2041945154 cites W2108929992 @default.
• W2041945154 cites W2109183238 @default.
• W2041945154 cites W2109195195 @default.
• W2041945154 cites W2110664911 @default.
• W2041945154 cites W2110755408 @default.
• W2041945154 cites W2112799266 @default.
• W2041945154 cites W2112858189 @default.
• W2041945154 cites W2112902831 @default.
• W2041945154 cites W2115837368 @default.
• W2041945154 cites W2117893791 @default.
• W2041945154 cites W2127864194 @default.
• W2041945154 cites W2128489222 @default.
• W2041945154 cites W2131693276 @default.
• W2041945154 cites W2136557734 @default.
• W2041945154 cites W2136975675 @default.
• W2041945154 cites W2137124187 @default.
• W2041945154 cites W2139604675 @default.
• W2041945154 cites W2141572089 @default.
• W2041945154 cites W2144658220 @default.
• W2041945154 cites W2146290595 @default.
• W2041945154 cites W2160934269 @default.
• W2041945154 cites W2161339576 @default.
• W2041945154 cites W2162157671 @default.
• W2041945154 cites W2164128387 @default.
• W2041945154 cites W2166369726 @default.
• W2041945154 cites W2167929690 @default.

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