Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041947836> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2041947836 endingPage "100" @default.
- W2041947836 startingPage "97" @default.
- W2041947836 abstract "Twenty-two synthetic proteinase inhibitors were tested for their inhibitory properties towards human acrosin. p-Nitrophenyl-p1-guanidino benzoate (NPGB) was the most effective (K1 value of 1-5 X 10(-8) M), producing a non-competitive type of inhibition in contrast to all other inhibitors which showed a competitive type of inhibition. The Michaelis constant for human acrosin on BAEE at pH 8-1 was calculated to be 4-25 X 10(-5) M.The neutral acrosomal proteinase, acrosin, has been found in the spermatozoa from many species. The addition of naturally occurring or synthetic inhibitors of acrosin to capacitated spermatozoa prevents fertilization, and synthetic acrosin inhibitors prevent fertilization by ejaculated spermatozoa while natural inhibitors do not. It was therefore thought possible that the synthetic inhibitors might be developed as contraceptive agents. In this study 22 synthetic proteinase inhibitors were tested in relation to human acrosin. Techniques used are described. The most effective compound was p-nitrophenyl-p'-guanidino benzoate (NPGB), which produced a noncompetitive type of inhibition. Some others tested showed a competitive type of inhibition. They were at least 200-3000 times less effective than NPGB. The high affinity of human acrosin for NPGB suggests that the enzyme has a serine group at its active site. Results indicate that NPGB has a greater protential as an antifertility agent than any other inhibitor tested." @default.
- W2041947836 created "2016-06-24" @default.
- W2041947836 creator A5003503145 @default.
- W2041947836 creator A5004441139 @default.
- W2041947836 creator A5020249325 @default.
- W2041947836 creator A5061727390 @default.
- W2041947836 creator A5074048534 @default.
- W2041947836 date "1976-05-01" @default.
- W2041947836 modified "2023-09-27" @default.
- W2041947836 title "Inhibition of human sperm acrosin by synthetic agents" @default.
- W2041947836 cites W1517725313 @default.
- W2041947836 cites W1978888479 @default.
- W2041947836 cites W1990875991 @default.
- W2041947836 cites W2001335860 @default.
- W2041947836 cites W2017167805 @default.
- W2041947836 cites W2027383144 @default.
- W2041947836 cites W2095240303 @default.
- W2041947836 cites W2096255497 @default.
- W2041947836 cites W2104237574 @default.
- W2041947836 cites W2163823392 @default.
- W2041947836 cites W2268100903 @default.
- W2041947836 cites W2277241642 @default.
- W2041947836 doi "https://doi.org/10.1530/jrf.0.0470097" @default.
- W2041947836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1271380" @default.
- W2041947836 hasPublicationYear "1976" @default.
- W2041947836 type Work @default.
- W2041947836 sameAs 2041947836 @default.
- W2041947836 citedByCount "21" @default.
- W2041947836 countsByYear W20419478362012 @default.
- W2041947836 crossrefType "journal-article" @default.
- W2041947836 hasAuthorship W2041947836A5003503145 @default.
- W2041947836 hasAuthorship W2041947836A5004441139 @default.
- W2041947836 hasAuthorship W2041947836A5020249325 @default.
- W2041947836 hasAuthorship W2041947836A5061727390 @default.
- W2041947836 hasAuthorship W2041947836A5074048534 @default.
- W2041947836 hasBestOaLocation W20419478361 @default.
- W2041947836 hasConcept C105702510 @default.
- W2041947836 hasConcept C150757390 @default.
- W2041947836 hasConcept C181199279 @default.
- W2041947836 hasConcept C185592680 @default.
- W2041947836 hasConcept C2776414213 @default.
- W2041947836 hasConcept C2777447553 @default.
- W2041947836 hasConcept C2778252442 @default.
- W2041947836 hasConcept C2781087480 @default.
- W2041947836 hasConcept C54355233 @default.
- W2041947836 hasConcept C55493867 @default.
- W2041947836 hasConcept C86803240 @default.
- W2041947836 hasConcept C88972607 @default.
- W2041947836 hasConceptScore W2041947836C105702510 @default.
- W2041947836 hasConceptScore W2041947836C150757390 @default.
- W2041947836 hasConceptScore W2041947836C181199279 @default.
- W2041947836 hasConceptScore W2041947836C185592680 @default.
- W2041947836 hasConceptScore W2041947836C2776414213 @default.
- W2041947836 hasConceptScore W2041947836C2777447553 @default.
- W2041947836 hasConceptScore W2041947836C2778252442 @default.
- W2041947836 hasConceptScore W2041947836C2781087480 @default.
- W2041947836 hasConceptScore W2041947836C54355233 @default.
- W2041947836 hasConceptScore W2041947836C55493867 @default.
- W2041947836 hasConceptScore W2041947836C86803240 @default.
- W2041947836 hasConceptScore W2041947836C88972607 @default.
- W2041947836 hasIssue "1" @default.
- W2041947836 hasLocation W20419478361 @default.
- W2041947836 hasLocation W20419478362 @default.
- W2041947836 hasOpenAccess W2041947836 @default.
- W2041947836 hasPrimaryLocation W20419478361 @default.
- W2041947836 hasRelatedWork W1946891264 @default.
- W2041947836 hasRelatedWork W1991704292 @default.
- W2041947836 hasRelatedWork W1993997945 @default.
- W2041947836 hasRelatedWork W2042390149 @default.
- W2041947836 hasRelatedWork W2095400169 @default.
- W2041947836 hasRelatedWork W2146064639 @default.
- W2041947836 hasRelatedWork W2361408231 @default.
- W2041947836 hasRelatedWork W2384394190 @default.
- W2041947836 hasRelatedWork W2416468294 @default.
- W2041947836 hasRelatedWork W3030870441 @default.
- W2041947836 hasVolume "47" @default.
- W2041947836 isParatext "false" @default.
- W2041947836 isRetracted "false" @default.
- W2041947836 magId "2041947836" @default.
- W2041947836 workType "article" @default.