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• W2041981330 abstract "This short communication reports on the innovative method of the local micro-invasive needle electroporation (LOMINE) of single adherent cells. The investigation of cellular reactions in living cell cultures represents a fundamental method, e.g. for drug development and environmental monitoring. Existing classical methods for intracellular measurements using, e.g. patch clamp techniques are time-consuming and complex. Present patch-on-chip systems are limited to the investigation of single cells in suspension. Nevertheless, the most part of the cells of the human body is adherently growing. Therefore, we develop a new chip system for the growth of adherent cells with 64 micro-structured needle electrodes as well as 128 dielectrophoretic electrodes, located within a measuring area of 1 mm(2). With this analytical chip, the intracellular investigation of electro-chemical changes and processes in adherently growing cells will become possible in the near future. Here, we present first intracellular measurements with this chip system." @default.
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• W2041981330 date "2010-12-01" @default.
• W2041981330 modified "2023-09-26" @default.
• W2041981330 title "Recording electric potentials from single adherent cells with 3D microelectrode arrays after local electroporation" @default.
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• W2041981330 doi "https://doi.org/10.1016/j.bios.2010.08.003" @default.
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