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- W2041984009 abstract "Mucosal lymphocyte homeostasis involves the dynamic interaction of enteric microbiota, the intestinal host epithelium, and the mucosal immune system. Dysregulation of mucosal lymphocyte homeostasis results in a variety of intestinal disorders, notably inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. One key cellular component regulating homeostasis are B lymphocytes that reside in gut-associated lymphoid tissue. This compartment includes Peyer’s patches, isolated lymphoid follicles, lamina propria, and mesenteric lymph nodes. Recent data have pointed to two new and exciting aspects of B cells in the gut. First, there has been progress on identification and functional analysis of abundant isolated lymphoid follicle B cells that are key mediators of IgA genesis. Second, several groups have now clarified the functional identification and characterization of immunoregulatory B cells in the gut. This review examines the novel aspects of these B cells, and examines how each plays a role in mediating mucosal homeostasis in this bacteria-laden compartment." @default.
- W2041984009 created "2016-06-24" @default.
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- W2041984009 date "2004-12-18" @default.
- W2041984009 modified "2023-10-14" @default.
- W2041984009 title "Surveillance B lymphocytes and mucosal immunoregulation" @default.
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- W2041984009 doi "https://doi.org/10.1007/s00281-004-0189-8" @default.
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