FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041989558> ?p ?o ?g. }

• W2041989558 endingPage "812" @default.
• W2041989558 startingPage "803" @default.
• W2041989558 abstract "<h3>Background & Aims</h3> Due to its anatomic connection, the liver is constantly exposed to gut-derived bacterial products or metabolites. Disruption of gut homeostasis is associated with many human diseases. The aim of this study was to determine the role of gut homeostasis in initiation and progression of hepatocellular carcinoma (HCC). <h3>Methods</h3> Disruption of intestinal homeostasis by penicillin or dextran sulfate sodium (DSS) and its restoration by probiotics were applied in a diethylnitrosamine (DEN) model of rat hepatocarcinogenesis. <h3>Results</h3> Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels. Chronic DEN treatment of rats was associated with an imbalance of subpopulations of the gut microflora including a significant suppression of <i>Lactobacillus</i> species, <i>Bifidobacterium</i> species and <i>Enterococcus</i> species as well as intestinal inflammation. Induction of enteric dysbacteriosis or intestinal inflammation by penicillin or DSS, respectively, significantly promoted tumor formation. Administration of probiotics dramatically mitigated enteric dysbacteriosis, ameliorated intestinal inflammation, and most importantly, decreased liver tumor growth and multiplicity. Interestingly, probiotics not only inhibited the translocation of endotoxin, which bears pathogen-associated molecular patterns (PAMPs) but also the activation of damage-associated molecular patterns (DAMPs) such as high-mobility group box 1 (HMGB1). As a result, the production of pro- and anti-inflammatory cytokines was skewed in favor of a reduced tumorigenic inflammation in the liver. <h3>Conclusions</h3> The data highlights the importance of gut homeostasis in the pathogenesis of HCC. Modulation of the gut microbiota by probiotics may represent a new avenue for therapeutic intervention to treat or prevent HCC development." @default.
• W2041989558 created "2016-06-24" @default.
• W2041989558 creator A5006625579 @default.
• W2041989558 creator A5012301761 @default.
• W2041989558 creator A5028612357 @default.
• W2041989558 creator A5029097014 @default.
• W2041989558 creator A5030250596 @default.
• W2041989558 creator A5034927282 @default.
• W2041989558 creator A5044395466 @default.
• W2041989558 creator A5047598263 @default.
• W2041989558 creator A5055838753 @default.
• W2041989558 creator A5055938506 @default.
• W2041989558 creator A5059729413 @default.
• W2041989558 creator A5060655239 @default.
• W2041989558 creator A5062795464 @default.
• W2041989558 creator A5068376674 @default.
• W2041989558 creator A5070834136 @default.
• W2041989558 creator A5074849517 @default.
• W2041989558 creator A5080853070 @default.
• W2041989558 creator A5080930329 @default.
• W2041989558 creator A5082734873 @default.
• W2041989558 creator A5084682935 @default.
• W2041989558 creator A5084727740 @default.
• W2041989558 date "2012-10-01" @default.
• W2041989558 modified "2023-10-13" @default.
• W2041989558 title "Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats" @default.
• W2041989558 cites W1601070312 @default.
• W2041989558 cites W168123579 @default.
• W2041989558 cites W1966651323 @default.
• W2041989558 cites W1985462428 @default.
• W2041989558 cites W2004266769 @default.
• W2041989558 cites W2014216380 @default.
• W2041989558 cites W2025986883 @default.
• W2041989558 cites W2028935045 @default.
• W2041989558 cites W2031801942 @default.
• W2041989558 cites W2039845199 @default.
• W2041989558 cites W2055791442 @default.
• W2041989558 cites W2064858042 @default.
• W2041989558 cites W2065429935 @default.
• W2041989558 cites W2065448523 @default.
• W2041989558 cites W2067400614 @default.
• W2041989558 cites W2080195364 @default.
• W2041989558 cites W2085153086 @default.
• W2041989558 cites W2088155518 @default.
• W2041989558 cites W2088629624 @default.
• W2041989558 cites W2094514571 @default.
• W2041989558 cites W2096566061 @default.
• W2041989558 cites W2105960411 @default.
• W2041989558 cites W2106039427 @default.
• W2041989558 cites W2118278569 @default.
• W2041989558 cites W2127132547 @default.
• W2041989558 cites W2131432706 @default.
• W2041989558 cites W2132551814 @default.
• W2041989558 cites W2139759128 @default.
• W2041989558 cites W2148300725 @default.
• W2041989558 cites W2151608099 @default.
• W2041989558 cites W2154954941 @default.
• W2041989558 cites W2315613727 @default.
• W2041989558 cites W78474113 @default.
• W2041989558 doi "https://doi.org/10.1016/j.jhep.2012.06.011" @default.
• W2041989558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22727732" @default.
• W2041989558 hasPublicationYear "2012" @default.
• W2041989558 type Work @default.
• W2041989558 sameAs 2041989558 @default.
• W2041989558 citedByCount "205" @default.
• W2041989558 countsByYear W20419895582013 @default.
• W2041989558 countsByYear W20419895582014 @default.
• W2041989558 countsByYear W20419895582015 @default.
• W2041989558 countsByYear W20419895582016 @default.
• W2041989558 countsByYear W20419895582017 @default.
• W2041989558 countsByYear W20419895582018 @default.
• W2041989558 countsByYear W20419895582019 @default.
• W2041989558 countsByYear W20419895582020 @default.
• W2041989558 countsByYear W20419895582021 @default.
• W2041989558 countsByYear W20419895582022 @default.
• W2041989558 countsByYear W20419895582023 @default.
• W2041989558 crossrefType "journal-article" @default.
• W2041989558 hasAuthorship W2041989558A5006625579 @default.
• W2041989558 hasAuthorship W2041989558A5012301761 @default.
• W2041989558 hasAuthorship W2041989558A5028612357 @default.
• W2041989558 hasAuthorship W2041989558A5029097014 @default.
• W2041989558 hasAuthorship W2041989558A5030250596 @default.
• W2041989558 hasAuthorship W2041989558A5034927282 @default.
• W2041989558 hasAuthorship W2041989558A5044395466 @default.
• W2041989558 hasAuthorship W2041989558A5047598263 @default.
• W2041989558 hasAuthorship W2041989558A5055838753 @default.
• W2041989558 hasAuthorship W2041989558A5055938506 @default.
• W2041989558 hasAuthorship W2041989558A5059729413 @default.
• W2041989558 hasAuthorship W2041989558A5060655239 @default.
• W2041989558 hasAuthorship W2041989558A5062795464 @default.
• W2041989558 hasAuthorship W2041989558A5068376674 @default.
• W2041989558 hasAuthorship W2041989558A5070834136 @default.
• W2041989558 hasAuthorship W2041989558A5074849517 @default.
• W2041989558 hasAuthorship W2041989558A5080853070 @default.
• W2041989558 hasAuthorship W2041989558A5080930329 @default.
• W2041989558 hasAuthorship W2041989558A5082734873 @default.
• W2041989558 hasAuthorship W2041989558A5084682935 @default.
• W2041989558 hasAuthorship W2041989558A5084727740 @default.

• next