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- W2041992758 abstract "FZR1, an activator of the anaphase-promoting complex/cyclosome (APC/C), is recognized for its roles in the mitotic cell cycle. To examine its meiotic function in females we generated an oocyte-specific knockout of the Fzr1 gene (Fzr1Δ/Δ). The total number of fully grown oocytes enclosed in cumulus complexes was 35-40% lower in oocytes from Fzr1Δ/Δ mice and there was a commensurate rise in denuded, meiotically advanced and/or fragmented oocytes. The ability of Fzr1Δ/Δ oocytes to remain prophase I/germinal vesicle (GV) arrested in vitro was also compromised, despite the addition of the phosphodiesterase milrinone. Meiotic competency of smaller diameter oocytes was also accelerated by Fzr1 loss. Cyclin B1 levels were elevated ~5-fold in Fzr1Δ/Δ oocytes, whereas securin and CDC25B, two other APC/CFZR1 substrates, were unchanged. Cyclin B1 overexpression can mimic the effects of Fzr1 loss on GV arrest and here we show that cyclin B1 knockdown in Fzr1Δ/Δ oocytes affects the timing of meiotic resumption. Therefore, the effects of Fzr1 loss are mediated, at least in part, by raised cyclin B1. Thus, APC/CFZR1 activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption." @default.
- W2041992758 created "2016-06-24" @default.
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- W2041992758 creator A5072162290 @default.
- W2041992758 creator A5076487121 @default.
- W2041992758 creator A5088304007 @default.
- W2041992758 date "2011-03-01" @default.
- W2041992758 modified "2023-10-01" @default.
- W2041992758 title "The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes" @default.
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- W2041992758 doi "https://doi.org/10.1242/dev.059022" @default.
- W2041992758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21270054" @default.
- W2041992758 hasPublicationYear "2011" @default.
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