FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042007225> ?p ?o ?g. }

• W2042007225 endingPage "2297" @default.
• W2042007225 startingPage "2290" @default.
• W2042007225 abstract "The development of the olfactory system in vertebrates is a multistep process, in which several regulatory molecules are required at different stages. The development of the olfactory sensory epithelium and its projection to the olfactory bulb are both known to require the LIM-homeodomain transcription factor Lhx2. We examined whether Lhx2 plays a role in the development of the OB itself, as well as its projection to the olfactory cortex. Although there is no morphological OB protuberance in the Lhx2 mutant, mitral cells are normally specified and cluster in a displaced olfactory bulb-like structure (OBLS). The OBLS is not able to pioneer the lateral olfactory tract (LOT) projection in vivo or when provided control (host) telencephalic territory in an in vitro assay. Strikingly, the mutant OBLS is capable of projecting along the LOT if provided with an existing normal LOT in the host explant. This is the first report of a role for a transcription factor expressed in the OB that selectively affects the axon guidance but not the specification of mitral cells. Furthermore, the Lhx2 mutant lateral telencephalon does not support growth of an LOT projection from control OB explants. The defect correlates with the disruption of a cellular mechanism that is thought to be critical for LOT pathfinding: a specialized cell population, the “lot cells,” is mislocalized in the Lhx2 mutant. In addition, the expression of Sema6A is aberrantly upregulated. Together, these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection." @default.
• W2042007225 created "2016-06-24" @default.
• W2042007225 creator A5023344879 @default.
• W2042007225 creator A5024742527 @default.
• W2042007225 creator A5042307095 @default.
• W2042007225 creator A5052699861 @default.
• W2042007225 date "2007-02-28" @default.
• W2042007225 modified "2023-09-23" @default.
• W2042007225 title "Dual Role for LIM-Homeodomain Gene<i>Lhx2</i>in the Formation of the Lateral Olfactory Tract" @default.
• W2042007225 cites W1768291799 @default.
• W2042007225 cites W1884185558 @default.
• W2042007225 cites W1919814413 @default.
• W2042007225 cites W1970681659 @default.
• W2042007225 cites W1973581291 @default.
• W2042007225 cites W1985774944 @default.
• W2042007225 cites W1993965691 @default.
• W2042007225 cites W2002662423 @default.
• W2042007225 cites W2008501231 @default.
• W2042007225 cites W2009045318 @default.
• W2042007225 cites W2015038624 @default.
• W2042007225 cites W2018499553 @default.
• W2042007225 cites W2029989368 @default.
• W2042007225 cites W2031912570 @default.
• W2042007225 cites W2036709282 @default.
• W2042007225 cites W2052065200 @default.
• W2042007225 cites W2052403342 @default.
• W2042007225 cites W2056330526 @default.
• W2042007225 cites W2059613892 @default.
• W2042007225 cites W2060893463 @default.
• W2042007225 cites W2061172411 @default.
• W2042007225 cites W2065668335 @default.
• W2042007225 cites W2068760639 @default.
• W2042007225 cites W2071804523 @default.
• W2042007225 cites W2071850720 @default.
• W2042007225 cites W2072332375 @default.
• W2042007225 cites W2073478649 @default.
• W2042007225 cites W2077140311 @default.
• W2042007225 cites W2077748997 @default.
• W2042007225 cites W2093786414 @default.
• W2042007225 cites W2116044769 @default.
• W2042007225 cites W2117552186 @default.
• W2042007225 cites W2120288525 @default.
• W2042007225 cites W2139808477 @default.
• W2042007225 cites W2141759106 @default.
• W2042007225 cites W2146470133 @default.
• W2042007225 cites W2156775517 @default.
• W2042007225 cites W2158014642 @default.
• W2042007225 cites W2158499654 @default.
• W2042007225 cites W2160287079 @default.
• W2042007225 doi "https://doi.org/10.1523/jneurosci.5571-06.2007" @default.
• W2042007225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2092498" @default.
• W2042007225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329426" @default.
• W2042007225 hasPublicationYear "2007" @default.
• W2042007225 type Work @default.
• W2042007225 sameAs 2042007225 @default.
• W2042007225 citedByCount "28" @default.
• W2042007225 countsByYear W20420072252012 @default.
• W2042007225 countsByYear W20420072252013 @default.
• W2042007225 countsByYear W20420072252014 @default.
• W2042007225 countsByYear W20420072252015 @default.
• W2042007225 countsByYear W20420072252016 @default.
• W2042007225 countsByYear W20420072252018 @default.
• W2042007225 countsByYear W20420072252019 @default.
• W2042007225 countsByYear W20420072252020 @default.
• W2042007225 countsByYear W20420072252021 @default.
• W2042007225 countsByYear W20420072252022 @default.
• W2042007225 crossrefType "journal-article" @default.
• W2042007225 hasAuthorship W2042007225A5023344879 @default.
• W2042007225 hasAuthorship W2042007225A5024742527 @default.
• W2042007225 hasAuthorship W2042007225A5042307095 @default.
• W2042007225 hasAuthorship W2042007225A5052699861 @default.
• W2042007225 hasBestOaLocation W20420072251 @default.
• W2042007225 hasConcept C104317684 @default.
• W2042007225 hasConcept C105702510 @default.
• W2042007225 hasConcept C121587040 @default.
• W2042007225 hasConcept C143065580 @default.
• W2042007225 hasConcept C169760540 @default.
• W2042007225 hasConcept C201792869 @default.
• W2042007225 hasConcept C2780496858 @default.
• W2042007225 hasConcept C51816534 @default.
• W2042007225 hasConcept C529278444 @default.
• W2042007225 hasConcept C533869091 @default.
• W2042007225 hasConcept C54355233 @default.
• W2042007225 hasConcept C86339819 @default.
• W2042007225 hasConcept C86803240 @default.
• W2042007225 hasConcept C95444343 @default.
• W2042007225 hasConceptScore W2042007225C104317684 @default.
• W2042007225 hasConceptScore W2042007225C105702510 @default.
• W2042007225 hasConceptScore W2042007225C121587040 @default.
• W2042007225 hasConceptScore W2042007225C143065580 @default.
• W2042007225 hasConceptScore W2042007225C169760540 @default.
• W2042007225 hasConceptScore W2042007225C201792869 @default.
• W2042007225 hasConceptScore W2042007225C2780496858 @default.
• W2042007225 hasConceptScore W2042007225C51816534 @default.
• W2042007225 hasConceptScore W2042007225C529278444 @default.
• W2042007225 hasConceptScore W2042007225C533869091 @default.
• W2042007225 hasConceptScore W2042007225C54355233 @default.
• W2042007225 hasConceptScore W2042007225C86339819 @default.

• next