FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042007534> ?p ?o ?g. }

• W2042007534 endingPage "1778" @default.
• W2042007534 startingPage "1768" @default.
• W2042007534 abstract "The nature of metabotropic purinergic and muscarinic receptor-mediated increases in intracellular calcium in primary rat neocortical neurons and glial cells has been investigated using fluorescence imaging techniques. Bath-application of ATP and muscarine (10 microM) elicited a characteristic increase in intracellular calcium in both neurons and glial cells. The profile of this response consisted of an initial transient increase followed by a sustained elevation (the plateau phase) which was dependent on extracellular calcium. Examination of the pharmacological basis of the purinergic receptor-mediated calcium response using 10 microM 2-methyl-thio ATP (MeS-ATP) and UTP revealed that P(2Y) receptor activation underlies this response. The calcium influx pathway responsible for the sustained calcium response was inhibited by metal ions. In both cell types La(3+) and Zn(2+) (100 microM) effectively inhibited the plateau phase of the response, whilst 100 microM Ni(2+) had little or no effect. In conclusion, P(2Y) purinergic and muscarinic receptor activation evoke a sustained increase in intracellular calcium in neocortical neurons and glial cells. This response has similar characteristics to that we have previously described following mGlu(5) activation. We propose that in these cell types stimulation of metabotropic receptors coupled to phosphoinositide turnover activates a common calcium entry pathway that is distinct from voltage-gated calcium channels and resembles store-operated calcium entry." @default.
• W2042007534 created "2016-06-24" @default.
• W2042007534 creator A5014692107 @default.
• W2042007534 creator A5037530098 @default.
• W2042007534 creator A5038178410 @default.
• W2042007534 date "2000-09-01" @default.
• W2042007534 modified "2023-09-27" @default.
• W2042007534 title "Purinergic and muscarinic receptor activation activates a common calcium entry pathway in rat neocortical neurons and glial cells" @default.
• W2042007534 cites W1968700446 @default.
• W2042007534 cites W1970415139 @default.
• W2042007534 cites W1971162500 @default.
• W2042007534 cites W1971209872 @default.
• W2042007534 cites W1974795398 @default.
• W2042007534 cites W1980166477 @default.
• W2042007534 cites W1991262933 @default.
• W2042007534 cites W1993610211 @default.
• W2042007534 cites W1995048591 @default.
• W2042007534 cites W2000228774 @default.
• W2042007534 cites W2003058141 @default.
• W2042007534 cites W2004851466 @default.
• W2042007534 cites W2005124478 @default.
• W2042007534 cites W2012000640 @default.
• W2042007534 cites W2027126767 @default.
• W2042007534 cites W2027213113 @default.
• W2042007534 cites W2030195151 @default.
• W2042007534 cites W2030999388 @default.
• W2042007534 cites W2031133615 @default.
• W2042007534 cites W2041690080 @default.
• W2042007534 cites W2071184494 @default.
• W2042007534 cites W2079878570 @default.
• W2042007534 cites W2084784491 @default.
• W2042007534 cites W2096437759 @default.
• W2042007534 cites W2113630547 @default.
• W2042007534 cites W2133159119 @default.
• W2042007534 cites W2141260882 @default.
• W2042007534 cites W2157660452 @default.
• W2042007534 cites W2167766838 @default.
• W2042007534 cites W2169518110 @default.
• W2042007534 cites W4211044690 @default.
• W2042007534 doi "https://doi.org/10.1016/s0028-3908(00)00013-7" @default.
• W2042007534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10884558" @default.
• W2042007534 hasPublicationYear "2000" @default.
• W2042007534 type Work @default.
• W2042007534 sameAs 2042007534 @default.
• W2042007534 citedByCount "30" @default.
• W2042007534 countsByYear W20420075342012 @default.
• W2042007534 countsByYear W20420075342016 @default.
• W2042007534 countsByYear W20420075342017 @default.
• W2042007534 countsByYear W20420075342018 @default.
• W2042007534 countsByYear W20420075342023 @default.
• W2042007534 crossrefType "journal-article" @default.
• W2042007534 hasAuthorship W2042007534A5014692107 @default.
• W2042007534 hasAuthorship W2042007534A5037530098 @default.
• W2042007534 hasAuthorship W2042007534A5038178410 @default.
• W2042007534 hasConcept C134018914 @default.
• W2042007534 hasConcept C169760540 @default.
• W2042007534 hasConcept C170493617 @default.
• W2042007534 hasConcept C178790620 @default.
• W2042007534 hasConcept C181080969 @default.
• W2042007534 hasConcept C185592680 @default.
• W2042007534 hasConcept C18699975 @default.
• W2042007534 hasConcept C26702167 @default.
• W2042007534 hasConcept C2780841807 @default.
• W2042007534 hasConcept C28406088 @default.
• W2042007534 hasConcept C30979828 @default.
• W2042007534 hasConcept C33789571 @default.
• W2042007534 hasConcept C519063684 @default.
• W2042007534 hasConcept C55493867 @default.
• W2042007534 hasConcept C57306754 @default.
• W2042007534 hasConcept C61174792 @default.
• W2042007534 hasConcept C79879829 @default.
• W2042007534 hasConcept C86803240 @default.
• W2042007534 hasConcept C95444343 @default.
• W2042007534 hasConceptScore W2042007534C134018914 @default.
• W2042007534 hasConceptScore W2042007534C169760540 @default.
• W2042007534 hasConceptScore W2042007534C170493617 @default.
• W2042007534 hasConceptScore W2042007534C178790620 @default.
• W2042007534 hasConceptScore W2042007534C181080969 @default.
• W2042007534 hasConceptScore W2042007534C185592680 @default.
• W2042007534 hasConceptScore W2042007534C18699975 @default.
• W2042007534 hasConceptScore W2042007534C26702167 @default.
• W2042007534 hasConceptScore W2042007534C2780841807 @default.
• W2042007534 hasConceptScore W2042007534C28406088 @default.
• W2042007534 hasConceptScore W2042007534C30979828 @default.
• W2042007534 hasConceptScore W2042007534C33789571 @default.
• W2042007534 hasConceptScore W2042007534C519063684 @default.
• W2042007534 hasConceptScore W2042007534C55493867 @default.
• W2042007534 hasConceptScore W2042007534C57306754 @default.
• W2042007534 hasConceptScore W2042007534C61174792 @default.
• W2042007534 hasConceptScore W2042007534C79879829 @default.
• W2042007534 hasConceptScore W2042007534C86803240 @default.
• W2042007534 hasConceptScore W2042007534C95444343 @default.
• W2042007534 hasIssue "10" @default.
• W2042007534 hasLocation W20420075341 @default.
• W2042007534 hasLocation W20420075342 @default.
• W2042007534 hasOpenAccess W2042007534 @default.
• W2042007534 hasPrimaryLocation W20420075341 @default.
• W2042007534 hasRelatedWork W1989765482 @default.

• next