Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042019930> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2042019930 endingPage "766" @default.
- W2042019930 startingPage "760" @default.
- W2042019930 abstract "This study demonstrates for the first time that FOXM1c transactivates the murine E-cadherin promoter. It shows also that the purified DNA-binding domain of FOXM1c binds to the murine and human E-cadherin promoters in vitro, namely to a perfectly conserved FOXM1 site. Thus, this study identifies E-cadherin as a new direct FOXM1c target gene. This finding is surprising because E-cadherin is a tumor suppressor gene whereas FOXM1 is a proliferation-associated and tumorigenesis-promoting transcription factor. The transmembrane glycoprotein E-cadherin mediates cell-cell adhesion in adherens junctions. Its expression is frequently lost or reduced in human tumors, which correlates with poor prognosis. Downregulation of E-cadherin represents a central event in epithelial-to-mesenchymal transition. In contrast, FOXM1 contributes to oncogenic transformation and participates in tumor initiation and progression. It is overexpressed in many human cancers and a high FOXM1 level correlates with poor prognosis. FOXM1 stimulates cell proliferation and promotes cell cycle progression at the G1/S- and G2/M-transitions. The surprising finding that FOXM1c transactivates the promoter of the tumor suppressor gene E-cadherin points to a tumor-suppressive property of FOXM1. This view is supported by FOXM1's new tumor suppressor role as others reported that urethane-induced lung tumorigenesis is increased in mice with an endothelial cell-specific foxm1 deletion." @default.
- W2042019930 created "2016-06-24" @default.
- W2042019930 creator A5080044562 @default.
- W2042019930 date "2011-03-01" @default.
- W2042019930 modified "2023-10-15" @default.
- W2042019930 title "The transcription factor FOXM1c binds to and transactivates the promoter of the tumor suppressor gene<i>E-cadherin</i>" @default.
- W2042019930 doi "https://doi.org/10.4161/cc.10.5.14827" @default.
- W2042019930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21311221" @default.
- W2042019930 hasPublicationYear "2011" @default.
- W2042019930 type Work @default.
- W2042019930 sameAs 2042019930 @default.
- W2042019930 citedByCount "16" @default.
- W2042019930 countsByYear W20420199302013 @default.
- W2042019930 countsByYear W20420199302014 @default.
- W2042019930 countsByYear W20420199302016 @default.
- W2042019930 countsByYear W20420199302017 @default.
- W2042019930 countsByYear W20420199302018 @default.
- W2042019930 countsByYear W20420199302021 @default.
- W2042019930 countsByYear W20420199302023 @default.
- W2042019930 crossrefType "journal-article" @default.
- W2042019930 hasAuthorship W2042019930A5080044562 @default.
- W2042019930 hasBestOaLocation W20420199301 @default.
- W2042019930 hasConcept C101762097 @default.
- W2042019930 hasConcept C104317684 @default.
- W2042019930 hasConcept C127561419 @default.
- W2042019930 hasConcept C1491633281 @default.
- W2042019930 hasConcept C149402561 @default.
- W2042019930 hasConcept C150194340 @default.
- W2042019930 hasConcept C170240278 @default.
- W2042019930 hasConcept C201508349 @default.
- W2042019930 hasConcept C2778264664 @default.
- W2042019930 hasConcept C502942594 @default.
- W2042019930 hasConcept C54355233 @default.
- W2042019930 hasConcept C555283112 @default.
- W2042019930 hasConcept C86339819 @default.
- W2042019930 hasConcept C86803240 @default.
- W2042019930 hasConcept C95444343 @default.
- W2042019930 hasConceptScore W2042019930C101762097 @default.
- W2042019930 hasConceptScore W2042019930C104317684 @default.
- W2042019930 hasConceptScore W2042019930C127561419 @default.
- W2042019930 hasConceptScore W2042019930C1491633281 @default.
- W2042019930 hasConceptScore W2042019930C149402561 @default.
- W2042019930 hasConceptScore W2042019930C150194340 @default.
- W2042019930 hasConceptScore W2042019930C170240278 @default.
- W2042019930 hasConceptScore W2042019930C201508349 @default.
- W2042019930 hasConceptScore W2042019930C2778264664 @default.
- W2042019930 hasConceptScore W2042019930C502942594 @default.
- W2042019930 hasConceptScore W2042019930C54355233 @default.
- W2042019930 hasConceptScore W2042019930C555283112 @default.
- W2042019930 hasConceptScore W2042019930C86339819 @default.
- W2042019930 hasConceptScore W2042019930C86803240 @default.
- W2042019930 hasConceptScore W2042019930C95444343 @default.
- W2042019930 hasIssue "5" @default.
- W2042019930 hasLocation W20420199301 @default.
- W2042019930 hasLocation W20420199302 @default.
- W2042019930 hasOpenAccess W2042019930 @default.
- W2042019930 hasPrimaryLocation W20420199301 @default.
- W2042019930 hasRelatedWork W1761391800 @default.
- W2042019930 hasRelatedWork W2036699146 @default.
- W2042019930 hasRelatedWork W2042019930 @default.
- W2042019930 hasRelatedWork W2058577774 @default.
- W2042019930 hasRelatedWork W2101055857 @default.
- W2042019930 hasRelatedWork W2120492537 @default.
- W2042019930 hasRelatedWork W2128492601 @default.
- W2042019930 hasRelatedWork W2295615914 @default.
- W2042019930 hasRelatedWork W2774704971 @default.
- W2042019930 hasRelatedWork W2900650092 @default.
- W2042019930 hasVolume "10" @default.
- W2042019930 isParatext "false" @default.
- W2042019930 isRetracted "false" @default.
- W2042019930 magId "2042019930" @default.
- W2042019930 workType "article" @default.