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• W2042023634 abstract "The present study examines the frequency of the two main HFE mutations (C282Y and H63D) in a randomly selected population of 346 individuals including 201 DNA samples from women with cervical neoplasia (including high-grade squamous intraepithelial lesions and invasive squamous cell carcinoma) and a control population of 146 women from the same geographical area. We found a significantly lower risk of development of cervical neoplasia in H63D carriers (OR = 0.56; 95% CI 0.35–0.92; p = 0.01). Multivariate logistic regression analysis confirms this observation (OR = 0.55; 95% CI 0.35–0.88, p = 0.01). Regarding the C282Y mutation no association was found (OR = 1.32; 95% CI 0.53–3.33; p = 0.52). In addition, a significant difference between H63D carrier and non-carrier women on the time-to-onset of cervical lesions was observed (log-rank test: p = 0.0012). These results indicate that HFE could be considered a candidate modifier gene of viral-related neoplasia such as cervical carcinoma possibly by a dual role on iron metabolism and immunological system." @default.
• W2042023634 created "2016-06-24" @default.
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• W2042023634 date "2006-03-01" @default.
• W2042023634 modified "2023-10-17" @default.
• W2042023634 title "Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer" @default.
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• W2042023634 doi "https://doi.org/10.1016/j.bbrc.2005.12.174" @default.
• W2042023634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16414021" @default.
• W2042023634 hasPublicationYear "2006" @default.
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